4-Hydroxyquinazoline
|
- $5 - $912.9
- Product name: 4-Hydroxyquinazoline
- CAS: 491-36-1
- MF: C8H6N2O
- MW: 146.15
- EINECS:207-735-8
- MDL Number:MFCD00511302
- Synonyms:4(3H)-Quinazolone;4-Quinazolinone;Quinazolone, 4-;quinazolidin-4-one;1H-quinazolin-4-one;TIMTEC-BB SBB005858;AURORA 17795;4-HYDROXYQUINAZOLINE
36 prices
Selected condition：
Brand
- Acrotein
- AK Scientific
- Alfa Aesar
- Alichem
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Frontier Specialty Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- TCI Chemical
- TRC
- Usbiological
Package
- 20mg
- 25mg
- 5MG
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 2.5g
- 5g
- 10g
- 25g
- 50g
- 100g
- 500g
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging500g
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline
- Packaging25g
- Price$23
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberA17129
- Product description4-Hydroxyquinazoline, 98%
- Packaging10g
- Price$36.65
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberA17129
- Product description4-Hydroxyquinazoline, 98%
- Packaging50g
- Price$107.65
- Updated2024-03-01
- Buy
- ManufacturerAlichem
- Product number491361
- Product descriptionQuinazolin-4(3H)-one
- Packaging500g
- Price$518.42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203001
- Product descriptionQuinazolin-4(3H)-one 98%
- Packaging25mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203001
- Product descriptionQuinazolin-4(3H)-one 98%
- Packaging5g
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203001
- Product descriptionQuinazolin-4(3H)-one 98%
- Packaging25g
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203001
- Product descriptionQuinazolin-4(3H)-one 98%
- Packaging100g
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0375705
- Product description4-HYDROXYQUINAZOLINE 95.00%
- Packaging5MG
- Price$500.85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4524
- Product description4-HQN
- Packaging50mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4524
- Product description4-HQN
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN91938
- Product description4-Quinazolinone ≥98%
- Packaging20mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573353
- Product description4-Hydroxyquinazoline >98%
- Packaging100mg
- Price$397.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573353
- Product description4-Hydroxyquinazoline >98%
- Packaging250mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573353
- Product description4-Hydroxyquinazoline >98%
- Packaging1g
- Price$912.9
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 500g | $220 | 2021-12-16 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline | 25g | $23 | 2021-12-16 | Buy |
| Alfa Aesar | A17129 | 4-Hydroxyquinazoline, 98% | 10g | $36.65 | 2024-03-01 | Buy |
| Alfa Aesar | A17129 | 4-Hydroxyquinazoline, 98% | 50g | $107.65 | 2024-03-01 | Buy |
| Alichem | 491361 | Quinazolin-4(3H)-one | 500g | $518.42 | 2021-12-16 | Buy |
| Ambeed | A203001 | Quinazolin-4(3H)-one 98% | 25mg | $5 | 2021-12-16 | Buy |
| Ambeed | A203001 | Quinazolin-4(3H)-one 98% | 5g | $9 | 2021-12-16 | Buy |
| Ambeed | A203001 | Quinazolin-4(3H)-one 98% | 25g | $13 | 2021-12-16 | Buy |
| Ambeed | A203001 | Quinazolin-4(3H)-one 98% | 100g | $40 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0375705 | 4-HYDROXYQUINAZOLINE 95.00% | 5MG | $500.85 | 2021-12-16 | Buy |
| ApexBio Technology | A4524 | 4-HQN | 50mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | A4524 | 4-HQN | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| Arctom | CFN91938 | 4-Quinazolinone ≥98% | 20mg | $30 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573353 | 4-Hydroxyquinazoline >98% | 100mg | $397.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573353 | 4-Hydroxyquinazoline >98% | 250mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573353 | 4-Hydroxyquinazoline >98% | 1g | $912.9 | 2021-12-16 | Buy |
Properties
Melting point :216-219 °C (lit.)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.Related product price
- Furazolidone
$5-1380 - Sulfaquinoxaline
$65-957.1 - 2-Quinoxalinone
$6-625
Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
JingJiang Connect Chemical manufacturing Co., Ltd.
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
