4-HQN
Catalog No.
A4524
PARP inhibitor
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Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 146.15 |
| Cas No. | 491-36-1 |
| Formula | C8H6N2O |
| Solubility | ≥7.4 mg/mL in DMSO; insoluble in H2O; ≥4.55 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 1H-quinazolin-4-one |
| SDF | Download SDF |
| Canonical SMILES | C1=CC=C2C(=C1)C(=O)N=CN2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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