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ChemicalBook >> CAS DataBase List >> 4'-HYDROXYCHALCONE

4'-HYDROXYCHALCONE

4'-HYDROXYCHALCONE price.
  • $5 - $1137.68
  • Product name: 4'-HYDROXYCHALCONE
  • CAS: 2657-25-2
  • MF: C15H12O2
  • MW: 224.25
  • EINECS:
  • MDL Number:MFCD00016484
  • Synonyms:2-Benzal-4'-hydroxyacetophenone 2-Benzylidene-4'-hydroxyacetophenone;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one;4'-Hydroxychalcone,97%;4'-Hydroxychalcone 98%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone98%;HYDROXYCHALCONE, 4'-
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  • AHH
  • AK Scientific
  • Alfa Aesar
  • Alichem
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
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  • CSNpharm
  • Matrix Scientific
  • Oakwood
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Package
  • 100mg
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  • 500g
  • ManufacturerAHH
  • Product numberMT-14943
  • Product description4'-Hydroxychalcone 97%
  • Packaging500g
  • Price$535
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ92680
  • Product description4'-Hydroxychalcone
  • Packaging100g
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA10838
  • Product description4'-Hydroxychalcone, 97%
  • Packaging25g
  • Price$180.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA10838
  • Product description4'-Hydroxychalcone, 97%
  • Packaging5g
  • Price$48.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlichem
  • Product number2657252
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one
  • Packaging100g
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging1g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging5g
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging10g
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging25g
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131746
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging100g
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberNUT0000057
  • Product description4'-HYDROXYCHALCONE 95.00%
  • Packaging5G
  • Price$773.85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberNUT0000057
  • Product description4'-HYDROXYCHALCONE 95.00%
  • Packaging25G
  • Price$1137.68
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22898
  • Product description4'-hydroxy Chalcone ≥98%
  • Packaging5g
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22898
  • Product description4'-hydroxy Chalcone ≥98%
  • Packaging10g
  • Price$78
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22898
  • Product description4'-hydroxy Chalcone ≥98%
  • Packaging25g
  • Price$161
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-14943 4'-Hydroxychalcone 97% 500g $535 2021-12-16 Buy
AK Scientific J92680 4'-Hydroxychalcone 100g $150 2021-12-16 Buy
Alfa Aesar A10838 4'-Hydroxychalcone, 97% 25g $180.65 2024-03-01 Buy
Alfa Aesar A10838 4'-Hydroxychalcone, 97% 5g $48.65 2024-03-01 Buy
Alichem 2657252 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 100g $208 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 100mg $5 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 1g $9 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 5g $16 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 10g $28 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 25g $54 2021-12-16 Buy
Ambeed A131746 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 100g $185 2021-12-16 Buy
American Custom Chemicals Corporation NUT0000057 4'-HYDROXYCHALCONE 95.00% 5G $773.85 2021-12-16 Buy
American Custom Chemicals Corporation NUT0000057 4'-HYDROXYCHALCONE 95.00% 25G $1137.68 2021-12-16 Buy
Cayman Chemical 22898 4'-hydroxy Chalcone ≥98% 5g $44 2024-03-01 Buy
Cayman Chemical 22898 4'-hydroxy Chalcone ≥98% 10g $78 2024-03-01 Buy
Cayman Chemical 22898 4'-hydroxy Chalcone ≥98% 25g $161 2024-03-01 Buy

Properties

Melting point :174-178 °C
Boiling point :419.6±45.0 °C(Predicted)
Density :1.191±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
form :powder to crystal
pka :7.72±0.15(Predicted)
color :Light orange to Yellow to Green
BRN :2049150
InChIKey :UAHGNXFYLAJDIN-IZZDOVSWSA-N
LogP :3.650 (est)
CAS DataBase Reference :2657-25-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.

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