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2-CHLOROLEPIDINE

2-CHLOROLEPIDINE ??? ???
?? ??:
634-47-9
???:
2-CHLOROLEPIDINE
???(??):
AKOS BB-6898;Chlorolepidine;3-chlorolepidine;2-CHLOROLEPIDINE;AKOS BBS-00000215;Lepidine, 2-chloro-;2-Chlorolepidine >OTAVA-BB BB0116110026;2-chloro-4-methyl-quinolin;2-CHLORO-4-METHYLQUINOLINE
CBNumber:
CB9663910
???:
C10H8ClN
??? ??:
177.63
MOL ??:
634-47-9.mol

2-CHLOROLEPIDINE ??

???
55-58 °C(lit.)
?? ?
296 °C(lit.)
??
1.1810 (rough estimate)
???
1.6224 (estimate)
???
296°C
?? ??
Inert atmosphere,Room Temperature
??? ??
powder to crystal
?? ?? (pKa)
0.98±0.50(Predicted)
??
???? ?? ??
BRN
118333
CAS ??????
634-47-9(CAS DataBase Reference)
NIST
Quinoline, 2-chloro-4-methyl-(634-47-9)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-37/39-36-24/25
WGK ?? 3
HS ?? 29334900
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
2 0

2-CHLOROLEPIDINE C??? ??, ??, ??

??? ??

white to light yellow crystal powder

??

2-Chloro-4-methyl-quinoline is a useful synthetic intermediate. It is an intermediate used to synthesize 4-Methyl-2-(1-piperidinyl)-quinoline (M320715) which is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. 2-Chloro-4-methyl-quinoline is also considered as a cyanine dye.

Synthesis Reference(s)

Journal of the American Chemical Society, 63, p. 2367, 1941 DOI: 10.1021/ja01854a016
Organic Syntheses, Coll. Vol. 3, p. 194, 1955

2-CHLOROLEPIDINE ?? ?? ? ???

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2-CHLOROLEPIDINE ?? ??

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2-CHLOROLEPIDINE ?? ??:

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