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17(R)-Resolvin D1 methyl ester

17(R)-Resolvin D1 methyl ester ??? ???

?? ??:: 937738-64-2

???:: 17(R)-Resolvin D1 methyl ester

???(??):: WUKVAFWBFGABJN-PFYFFMTHSA-N;17(R)-Resolvin D1 methyl ester;4,9,11,13,15,19-Docosahexaenoic acid, 7,8,17-trihydroxy-, methyl ester, (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)-

CBNumber:: CB93152925

???:: C23H34O5

??? ??:: 390.51

MOL ??:: 937738-64-2.mol

?? ?? 10

17(R)-Resolvin D1 methyl ester ??

?? ?: 562.1±50.0 °C(Predicted)

??: 1.064±0.06 g/cm3(Predicted)

?? ??: Store at -20°C

???: DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml

?? ?? (pKa): 13.33±0.20(Predicted)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H225	???? ?? ? ??	??? ??	?? 2	??		P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??		P264, P280, P305+P351+P338,P337+P313P

??????:

P210	?·???·??·????? ????? - ?? ???.
P233	??? ??? ?????. ??? ??? ? ?? ?? ??? ???? ?????.
P240	??? ????? ?? ? ??????.
P241	?? ??? ??[???/??/??/...]?(?) ?????.
P242	???? ???? ?? ??? ?????
P243	??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P280	????/???/???/?????? ?????.
P303+P361+P353	??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P370+P378	?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
P403+P235	??? ? ?? ?? ???? ???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	3
2		0

17(R)-Resolvin D1 methyl ester C??? ??, ??, ??

??

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC₅₀ = ~30 nM). 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose. In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. 17(R)-RvD1 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.

17(R)-Resolvin D1 methyl ester ?? ?? ? ???

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?? ??

17(R)-Resolvin D1 methyl ester ?? ??

???( 10)?? ??

???	??	???	??	?? ?	??
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7978	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19703	58

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