PIVMECILLINAM
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PIVMECILLINAM ??
- ???
- 118-119 C
- ??
- D20 +231° (c = 1 in 96% ethanol)
- ?? ?
- 581.0±60.0 °C(Predicted)
- ??
- 1.30±0.1 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO: ???5mg/mL, ??(??)
- ??? ??
- ??
- ?? ?? (pKa)
- 8.11±0.60(Predicted)
- ??
- ???? ????
- optical activity
- [α]/D +215 to +245°, c = 1 in ethanol
??
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-37/39 | ||
| WGK ?? | 3 | ||
| RTECS ?? | XI0185000 | ||
| ?? | LD50 in mice, rats (mg/kg): 475-480, 465 i.v.; 1736-1930, 1935-2100 s.c.; 3020, 9500-10000 orally (Sato) |
PIVMECILLINAM C??? ??, ??, ??
??
Pivmecillinam was found by a series of studies at Leo in 1969. It is a derivative of 6βformamidinopenicillanic acid and shows strong activity against gram-negative bacilli. Pivmecillinam is hydrolyzed by intestinal esterase and acts similarly to mecillinam after oral administration. Mecillinam shows weaker activity than ampicillin against gram-positive cocci but much stronger activity against a wide range of gramnegative bacilli.??
Antibacterial.PIVMECILLINAM ?? ?? ? ???
???
?? ??
PIVMECILLINAM ?? ??
???( 43)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
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| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9305 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38630 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 |
info@allgreenchem.com | China | 5998 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |
| Shanghai Holy Biohemdeviser Co., Ltd | 021-61551100 |
China | 444 | 57 | |
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4861 | 58 |
| Suzhou ChemWe Chemical Co., Ltd. | 512-62706911 13401923197 |
sales@chemwe.com | China | 94 | 56 |
| SPIRO PHARMA | |
eric_feng1954@126.com | China | 9248 | 55 |
PIVMECILLINAM ?? ??:
???? ???? ???? ??-????? ?? ??????????? ???? ??
Cephalosporin
PIVMECILLINAM IMPURITY C
PIVMECILLINAM HYDROCHLORIDE
PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD)
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
4-METHOXY-2-METHYL-2-BUTANETHIOL
PIVMECILLINAM
pivalyloxymethyl butyrate