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C18 Globotriaosylceramide (d18:1/18:0)
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C18 Globotriaosylceramide (d18:1/18:0) ??
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- 1132.1±65.0 °C(Predicted)
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- 1.22±0.1 g/cm3(Predicted)
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- Store at -20°C
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- Chloroform:Methanol (2:1): Soluble; DMSO: Soluble; Methanol: Warmed
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- ?? ?? (pKa)
- 12.76±0.70(Predicted)
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C18 Globotriaosylceramide (d18:1/18:0) C??? ??, ??, ??
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C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. [Matreya, LLC. Catalog No. 1529]C18 Globotriaosylceramide (d18:1/18:0) ?? ?? ? ???
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C18 Globotriaosylceramide (d18:1/18:0) ?? ??
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