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1,1'-(Azodicarbonyl)-dipiperidine

1,1'-(Azodicarbonyl)-dipiperidine ??? ???
?? ??:
10465-81-3
???:
1,1'-(Azodicarbonyl)-dipiperidine
???(??):
ADDP;Diazene-1,2-diylbis(piperidin-1-ylMethanone);sr4077;NSC 356027;Azodicarboxylic;1,1'-(Azodicarbo;1,1'-(Azodicarbonyl);Diphenylpiperidylcarboxylate;AZODICARBOXYLIC DIPIPERIDIDE;1,1'-(azodicarbonyl)piperidine
CBNumber:
CB8352693
???:
C12H20N4O2
??? ??:
252.31
MOL ??:
10465-81-3.mol
MSDS ??:
SDS

1,1'-(Azodicarbonyl)-dipiperidine ??

???
132-136 °C(lit.)
?? ?
366.4±25.0 °C(Predicted)
??
1.29±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Sealed in dry,Room Temperature
???
DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
-0?+-.0.20(Predicted)
??
???
???
?? ?? ?????.
BRN
261917
InChI
InChI=1S/C12H20N4O2/c17-11(15-7-3-1-4-8-15)13-14-12(18)16-9-5-2-6-10-16/h1-10H2
InChIKey
OQJBFFCUFALWQL-UHFFFAOYSA-N
SMILES
N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O
CAS ??????
10465-81-3(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36
????(UN No.) 3234
WGK ?? 3
TSCA No
HS ?? 29339900
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
2 0

1,1'-(Azodicarbonyl)-dipiperidine C??? ??, ??, ??

??

1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.

??? ??

yellow crystalline powder

??

It is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.

?? ??

1,1'-(Azodicarbonyl)-dipiperidine can selectively oxidizes a variety of alcohols to the corresponding aldehydes or ketones under basic conditions.

1,1'-(Azodicarbonyl)-dipiperidine ?? ?? ? ???

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1,1'-(Azodicarbonyl)-dipiperidine ?? ??

???( 249)?? ??
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1,1'-(Azodicarbonyl)-dipiperidine ?? ??:

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