ChemicalBook >?? ???? >ANTI-ZAP-70
ANTI-ZAP-70
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ANTI-ZAP-70 ??
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- −20°C
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| ?? ???? ?? | 22 | ||
| WGK ?? | 3 |
ANTI-ZAP-70 C??? ??, ??, ??
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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. (provided by RefSeq)ANTI-ZAP-70 ?? ?? ? ???
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ANTI-ZAP-70 ?? ??
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