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YH239-EE

YH239-EE ??? ???
?? ??:
1364488-67-4
???:
YH239-EE
???(??):
CS-1286;YH239-EE;YH239-EE USP/EP/BP;YH 239-EE;YH 239 EE;YH239-EE, 10 mM in DMSO;Ethyl 3-[2-(tert-Butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoet;Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-;Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate;ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate;1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester
CBNumber:
CB82710411
???:
C25H27Cl2N3O4
??? ??:
504.41
MOL ??:
1364488-67-4.mol

YH239-EE ??

?? ?
763.3±60.0 °C(Predicted)
??
1.313±0.06 g/cm3(Predicted)
?? ??
Desiccate at -20°C
???
≥50.4 mg/mL in DMSO; insoluble in H2O; ≥4.26 mg/mL in EtOH with ultrasonic
??? ??
??
??? ??
??? ??
?? ?? (pKa)
13.20±0.30(Predicted)
??
White to off-white
??
  • ?? ? ?? ??
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
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??????:
NFPA 704
0
2 0

YH239-EE C??? ??, ??, ??

??

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

YH239-EE ?? ?? ? ???

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YH239-EE ?? ??

???( 93)?? ??
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YH239-EE ?? ??:

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