Rosiglitazone
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Rosiglitazone ??
- ???
- 153-155 C
- ?? ?
- 585.0±35.0 °C(Predicted)
- ??
- 1.315±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO: ≥10mg/mL
- ?? ?? (pKa)
- 6.34±0.50(Predicted)
- ??? ??
- ??
- ??
- ???? ?????
- Merck
- 14,8265
- CAS ??????
- 122320-73-4(CAS DataBase Reference)
- IARC
- 3 (Vol. 108) 2016
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/38 | ||
| ????? | 26-37/39 | ||
| WGK ?? | 3 | ||
| RTECS ?? | XJ5813850 | ||
| HS ?? | 2934100000 | ||
| ?? ?? ??? | 122320-73-4(Hazardous Substances Data) |
Rosiglitazone C??? ??, ??, ??
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Rosiglitazone is an insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).Indications
Rosiglitazone is approved for use as monotherapy and in conjunction with metformin, though it is sometimes combined with a sulfonylurea or insulin. It is usually taken once or twice a day with or without food. Rosiglitazone may cause a modest increase in lowdensity lipoprotein and triglyceride concentrations, but it is unclear whether this effect has any clinical significance or persists in the long term.?? ??
Rosiglitazone is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, and is availableas the maleate salt in tablets containing the drug alone(Avandia) or in combination products with metformin(Avandamet) or with glimepiride (Avandaryl). The2-aminopyridine moiety allows for salt formation; the marketedformulations contain the 1:1 salt with maleic acid, inwhich the pyridine nitrogen accepts a proton, forming the2-aminopyridinium species.Clinical Use
Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.Rosiglitazone ?? ?? ? ???
???
N,N-?????????
1.4-?????
??????????
2,4-????? ??
??
2-N-??-2-?????????
??????????
Acetic acid, [4-(hydroxymethyl)phenoxy]-, ethyl ester
196810-03-4
??????
4-[2-[??(???-2-YL)???]???]-?????
5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione
4-?????? ??
Rosiglitazone Related Compound A (25 mg) ((5Z)-5-{[4-({2-[methyl(2-pyridinyl)amino]ethyl}oxy)phenyl]methylidene}-1,3-thiazolidine-2,4-dione)
2-???????
2-??????
?? ??
Rosiglitazone ?? ??
???( 487)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 |
abby@chuanghaibio.com | China | 8808 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 10983 | 58 |
| Apeloa production Co.,Limited | +8619933239880 |
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| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 |
junhua1@hb-junhua.com | China | 978 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21628 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29858 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2930 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
Rosiglitazone ?? ??:
????-?? 3-?????? ???? ?? 2-?????? 4-?????????? ?????? ??? ?? 2,4-????? ??
Tribenuron methyl
PHENYL VALERATE
METSULFURON METHYL
Pioglitazone hydrochloride
Methyl
ROSIGLITAZONE HYDROCHLORIDE 99%,Rosiglitazone hydrochloride
rosiglitazone sodium
ROSIGLITAZONE MALEATE
2-[(N-METHYL-N-2-PYRIDINYL) AMINO]ETHANOL (FOR ROSIGLITAZONE)
Thiazole