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???[2,3-D]????-2,4(1H,3H)-??

???[2,3-D]????-2,4(1H,3H)-??
???[2,3-D]????-2,4(1H,3H)-?? ??? ???
?? ??:
21038-66-4
???:
???[2,3-D]????-2,4(1H,3H)-??
???(??):
???[2,3-D]????-2,4(1H,3H)-??
???:
PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
???(??):
Pyrido[2,3-d]pyrimidine-2,4-diol;Pyrido[2,3-d]pyrimidine-2,4(1H,3;Pyrido[2,3-d]pyrimidine-2,4(1H,3H);1H-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIONE;PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE;2,8,10-triazabicyclo[4.4.0]deca-2,4,11-triene-7,9-dione
CBNumber:
CB6449997
???:
C7H5N3O2
??? ??:
163.13
MOL ??:
21038-66-4.mol

???[2,3-D]????-2,4(1H,3H)-?? ??

???
361℃
??
1.424
?? ??
Sealed in dry,Room Temperature
?? ?? (pKa)
9.31±0.20(Predicted)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22
HS ?? 2933998090
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P362 ??? ??? ?? ?? ?? ?????
P501 ...? ??? / ??? ?? ???.

???[2,3-D]????-2,4(1H,3H)-?? C??? ??, ??, ??

??

Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione is used as an inhibitor of mTOR kinase.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 2256, 1955 DOI: 10.1021/ja01613a069

???[2,3-D]????-2,4(1H,3H)-?? ?? ?? ? ???

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???[2,3-D]????-2,4(1H,3H)-?? ?? ??

???( 116)?? ??
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???[2,3-D]????-2,4(1H,3H)-?? ?? ??:

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