ChemicalBook >?? ???? >XE 991 dihydrochloride
XE 991 dihydrochloride
|
|
XE 991 dihydrochloride ??
- ?? ??
- Store at -20°C
- ???
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
- ??? ??
- ??
- ??
- Off-white to light yellow
- ???
- ?? 100mM?? ???
??
XE 991 dihydrochloride C??? ??, ??, ??
??
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.??
XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.XE 991 dihydrochloride ?? ?? ? ???
???
?? ??
XE 991 dihydrochloride ?? ??
???( 44)?? ??
??? | ?? | ??? | ?? | ?? ? | ?? |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32957 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57505 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 |
China | 4566 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 |
2853530910@QQ.com | China | 8012 | 62 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 |
lucy@atkchemical.com | China | 9952 | 58 |