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?? ??:
10347-81-6
???:
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???(??):
??????????????;????? ????????;Maprotiline???
???:
Maprotiline hydrochloride
???(??):
ba34276;Psymion;Maprolu;Deprilept;ciba34276ba;LUDIOMIL HCL;Ludiomil tab;Einecs 233-758-8;Ludiomil comprimes;ciba34276hydrochloride
CBNumber:
CB6297617
???:
C20H24ClN
??? ??:
313.86
MOL ??:
10347-81-6.mol
MSDS ??:
SDS

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???
230-232°C
???
9℃
?? ??
2-8°C
???
H2O: 50 mg/mL
??? ??
??
??
???
???
?? 50mg/ml?? ?????. 10mM?? ???? ???
Merck
14,5748
InChI
InChI=1/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/t15-,20+;
InChIKey
NZDMFGKECODQRY-ZLYMRNBRNA-N
SMILES
[C@@]12(CCCNC)CC[C@@]([H])(C3C=CC=CC1=3)C1C=CC=CC2=1.Cl |&1:0,8,r|
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,T,F
?? ???? ?? 22-39/23/24/25-23/24/25-11
????? 7-16-36/37-45
????(UN No.) 3249
WGK ?? 3
RTECS ?? KJ4555000
?? ?? 6.1(b)
???? III
HS ?? 2921490002
?? LD50 in mice, rats (mg/kg): ~750, ~900 orally (Hess)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
NFPA 704
0
2 0

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Crystalline Solid

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Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.

?? ??

Maprotiline hydrochloride, N-methyl-9,10-ethanoanthracene-9(10H)-propanamine hydrochloride (Ludiomil), is sometimesdescribed as a tetracyclic rather than a tricyclic antidepressant.The description is chemically accurate, but the compound,nonetheless, conforms to the overall TCA pharmacophore. Itis a dibenzobicyclooctadiene and can be viewed as a TCAwith an ethylene-bridged central ring. The compound is notstrongly anticholinergic and has stimulant properties. It canhave effects on the cardiovascular system. It is a SNERI.

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Selective noradrenalin re-uptake inhibitor.

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