????
|
|
???? ??
- ???
- 211-213 °C (dec.) (lit.)
- ?? ?
- 272.96°C (rough estimate)
- ??
- 1.2933 (rough estimate)
- ???
- 1.4500 (estimate)
- ?? ??
- 2-8°C
- ???
- ???: 50mg/mL
- ??? ??
- ??
- ?? ?? (pKa)
- 4.58±0.10(Predicted)
- ??
- ????? ?????
- ???
- ??? ?? ???
- Merck
- 14,1635
- BRN
- 2210883
- ???
- ????. ?? ??. ?? ???, ?? ??? ???? ????.
- InChIKey
- QAIPRVGONGVQAS-DUXPYHPUSA-N
- LogP
- 1.150
- CAS ??????
- 331-39-5(CAS DataBase Reference)
- IARC
- 2B (Vol. 56) 1993
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-40-63-68 | ||
| ????? | 26-36/37/39-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | GD8950000 | ||
| ?? ?? ?? | Irritant | ||
| HS ?? | 29182990 | ||
| ?? ?? ??? | 331-39-5(Hazardous Substances Data) |
???? C??? ??, ??, ??
??
Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong), and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solutionCaffeic acid has both cis and trans isomers, and the two isomers of caffeic acid have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free state accounts for a few proportion.
??? ??
Light yellow to greenish-yellow powder??? ??
Appearance: yellow crystal. The crystal from the concentrated solution does not contain crystal water, and the crystal from the dilute solution contains one molecule crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in coldwater but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is orange-red. Ferric chloride solution was dark green.
??
Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.Indications
It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia.?? ??
Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.??? ?? ??
Insoluble in water.????
ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.????
Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.Purification Methods
Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]???? ?? ?? ? ???
???
Cyclohexanecarboxylic acid, 3-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxy-
Quinic acid
(E)-methyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate
3,4-???????????
7,8-Dihydroxycoumarin
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???? ?? ??
???( 801)?? ??
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