別名
4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione,E3 Ligase ligand methylated negative control,Ligand for PROTAC research
應(yīng)用
N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
其他說(shuō)明
Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC? Degraders for Targeted Protein DegradationHijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4Targeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein Degradation
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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