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GMB-475

GMB-475 ??? ???
?? ??:
2490599-18-1
???:
GMB-475
???(??):
GMB-475;GMB-475, 10 mM in DMSO;Bcr-Abl,GMB-475,PROTACs,GMB 475,Apoptosis,Inhibitor,inhibit,GMB475;(2S)-1-((R)-3,3-dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber:
CB58379743
???:
C43H46F3N7O7S
??? ??:
861.94
MOL ??:
2490599-18-1.mol

GMB-475 ??

?? ?
1029.7±65.0 °C(Predicted)
??
1.337±0.06 g/cm3(Predicted)
???
DMSO:145.4(Max Conc. mg/mL);168.69(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);58.01(Max Conc. mM)
??? ??
Solid
?? ?? (pKa)
13.50±0.46(Predicted)
??
Light yellow to yellow
InChIKey
ONDVWISBMHHLGZ-XAYQSWBHNA-N
SMILES
C(N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1)(=O)[C@H](C(C)(C)C)NC(=O)COCCOC1C=CC(C2=NC=NC(NC3C=CC(OC(F)(F)F)=CC=3)=C2)=CC=1 |&1:3,6,24,r|
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

GMB-475 C??? ??, ??, ??

???? ??

GMB-475, a BCR-ABL1 Inhibitor Based on PROTAC, Has the Potential to Overcome BCR-ABL1-Dependent Drug Resistance. In both human CML K562 cells and murine Ba/F3 cells expressing BCR-ABL1, GMB-475 induces rapid proteasomal degradation and inhibition of downstream biomarkers. Notably, GMB-475 inhibits the proliferation of certain clinically relevant BCR-ABL1 kinase domain point mutants. GMB-475 reduces viability and increases apoptosis in primary chronic myeloid leukemia CD34+ cells, with no effect on healthy CD34+ cells. Furthermore, GMB-475 degrades BCR-ABL1 and reduces cell viability in primary chronic myeloid leukemia stem cells.

GMB-475 ?? ?? ? ???

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GMB-475 ?? ??

???( 59)?? ??
??? ?? ??? ?? ?? ? ??
Hubei Chuchang Biotech Co., Ltd.
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TargetMol Chemicals Inc.
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InvivoChem
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Nantong HI-FUTURE Biology Co., Ltd.
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TargetMol Chemicals Inc.

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Jilin Chinese Academy of Sciences-yanshen Technology
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Aladdin Scientific

tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
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orders@jknbiochem.com China 5221 58
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618
sales@adobechem.com China 1250 50
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613
sales@chemrenpharm.com China 3600 58

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