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Linifanib (ABT-869)

Linifanib (ABT-869) ??? ???
?? ??:
796967-16-3
???:
Linifanib (ABT-869)
???(??):
RG3635;CS-178;ABT-869;AL-39324;Linifanib;Linifanib-d4;ABT-869 5.2G;AL39324,RG3635;Caswell No. 146;ABT-869、AL-39324
CBNumber:
CB52464951
???:
C21H18FN5O
??? ??:
375.4
MOL ??:
796967-16-3.mol

Linifanib (ABT-869) ??

???
180-183°C (dec.)
?? ?
542.2±50.0 °C(Predicted)
??
1.424
?? ??
-20°C Freezer
???
DMSO????? ???
?? ?? (pKa)
13.30±0.70(Predicted)
??? ??
?? ??.
??
????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 2933998090
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H361 ?? ?? ????? ??? ??? ??? ??? ???? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
H372 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ?? ???? ?? - ?? ?? ?? 1 ?? GHS hazard pictograms P260, P264, P270, P314, P501
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P260 ??·?·??·???·??·...·????? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P281 ???? ?? ???? ?????
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P314 ???? ??? ???? ??·??? ????.
P391 ???? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

Linifanib (ABT-869) C??? ??, ??, ??

??? ??

Beige Solid

??

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

??

ChEBI: A member of the class of ureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other nitrogen is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a poten , selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.

Linifanib (ABT-869) ?? ?? ? ???

???

?? ??


Linifanib (ABT-869) ?? ??

???( 191)?? ??
??? ?? ??? ?? ?? ? ??
Capot Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58

Linifanib (ABT-869) ?? ??:

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