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1,4-??[(p-???????)???]-?????

1,4-??[(p-???????)???]-?????
1,4-??[(p-???????)???]-????? ??? ???
?? ??:
96969-83-4
???:
1,4-??[(p-???????)???]-?????
???(??):
1,4-??[(p-???????)???]-?????
???:
1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone
???(??):
BML-266;JFD00244;JFD00244,JFD-00244;1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone;1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione;9,10-Anthracenedione, 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-
CBNumber:
CB52092329
???:
C30H26N2O4
??? ??:
478.54
MOL ??:
96969-83-4.mol

1,4-??[(p-???????)???]-????? ??

?? ?
780.2±60.0 °C(Predicted)
??
1.370±0.06 g/cm3(Predicted)
?? ??
Room temp
???
DMSO: ≥10mg/mL
?? ?? (pKa)
9.76±0.15(Predicted)
??? ??
??
??? ??
??? ??
??
???
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? N
?? ???? ?? 50/53
????? 60-61
????(UN No.) UN 3077 9/PG 3
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P273 ???? ???? ???.

1,4-??[(p-???????)???]-????? C??? ??, ??, ??

??

Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 μM). At 5 μM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.

1,4-??[(p-???????)???]-????? ?? ?? ? ???

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1,4-??[(p-???????)???]-????? ?? ??

???( 47)?? ??
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1,4-??[(p-???????)???]-????? ?? ??:

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