???????????????
|
|
??????????????? ??
- ???
- 203-204°
- ?? ??
- Inert atmosphere,2-8°C
- ???
- ?? ???(96%)? ?? ?? ??? ??????? ?? ?? ????.
- ?? ?? (pKa)
- pKa 8.0 (Uncertain);9.8 (Uncertain)
- ??? ??
- Solid
- ??
- White to off-white
- CAS ??????
- 579-56-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,N | ||
|---|---|---|---|
| ?? ???? ?? | 22-50/53-63-50 | ||
| ????? | 36-61-60 | ||
| ????(UN No.) | UN 3077 9 / PGIII | ||
| WGK ?? | 3 | ||
| RTECS ?? | DO8225000 | ||
| HS ?? | 2922504500 | ||
| ?? ?? ??? | 579-56-6(Hazardous Substances Data) | ||
| ?? | LD50 in rats (mg/kg): 1750 orally; 164 i.p. (Goldenthal) |
??????????????? C??? ??, ??, ??
??
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties. It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291). Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice. It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 μM). It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.??? ??
White Solid??
As a vasilodator drug, Isoxsuprine Hydrochloride is used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Isoxsuprine Hydrochloride has been shown to be a β-adrenoreceptor antagonist with β-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. Studies suggest that Isoxsuprine Hydrochloride may be useful as a as a tocolytic agent in the treatment of preterm labour.??????????????? ?? ?? ? ???
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???( 144)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21626 | 55 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29807 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 3974 | 58 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32277 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15227 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 |
info@finetechnology-ind.com | China | 9642 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38664 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 |
product@acmec-e.com | China | 33338 | 58 |
??????????????? ?? ??:
Bezafibrate
ISOXSUPRINE HYDROCHLORIDE MM(CRM STANDARD),ISOXSUPRINE HYDROCHLORIDE MM(CRM STANDARD)
ISOXSUPRINE HCL USP(CRM STANDARD)
Isoxsuprine acefyllinate
ISOXSUPRINE HYDROCHLORIDE EPI(CRM STANDARD),ISOXSUPRINE HYDROCHLORIDE EPI(CRM STANDARD)
Isoxsuprine (base and/or unspecified salts)
ISOXSUPRINE HYDROCHLORIDE,ISOXSUPRINE HCL,ISOXSUPRINE HYDROCHLORIDE
isoxsuprine lactate
Isoxsuprine base