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GC376

GC376 ??? ???

?? ??:: 1416992-39-6

???:: GC376

???(??):: 376;GC376 sodium;GC376;GPC376;GC376 Sodium Bulk;GC376 (sodium salt);GC-376 sodium,GC376 sodium;3 alpha, 7 alpha-dyhydroxy-6-ethidene- cholanic acid;sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4- methylpentanamido)- 1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane- 1-;Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

CBNumber:: CB43333611

???:: C21H32N3NaO8S

??? ??:: 509.55

MOL ??:: 1416992-39-6.mol

?? ?? 100

GC376 ??

?? ??: Inert atmosphere,Store in freezer, under -20°C

???: DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml

??? ??: ??? ??

?? ? ?? ??
?? ? ???? ?? (GHS)

HS ??	2933299090

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.

GC376 C??? ??, ??, ??

??

GC376 is an inhibitor of the main protease M^pro (3CL^pro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease M^pro (3CL^pro) from SARS-CoV-2 with IC₅₀ of 0.03 μM and EC₅₀ of 3.37 μM.

??

GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro.

GC376 ?? ?? ? ???

???

benzyl ((2S)-4-methyl-1-oxo-1-(((2S)-1-oxo-3-(2-oxo-1l2-pyrrolidin-3-yl)propan-2-yl)-l2-azanyl)pentan-2-yl)carbamate Methyl L-leucinate hydrochloride

?? ??

GC376 ?? ??

???( 100)?? ??

???	??	???	??	?? ?	??
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