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HuangjiangSu A

HuangjiangSu A ??? ???
?? ??:
1026020-27-8
???:
HuangjiangSu A
???(??):
HuangjiangSu A;β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-;(3beta,25R)-26-(beta-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranoside
CBNumber:
CB43037627
???:
C51H82O22
??? ??:
1047.2
MOL ??:
1026020-27-8.mol

HuangjiangSu A ??

???
274-276 °C
??
1.48±0.1 g/cm3(Predicted)
?? ??
Store at -20°C
???
DMSO? ???
?? ?? (pKa)
12?+-.0.70(Predicted)

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HuangjiangSu A C??? ??, ??, ??

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Huangjiangsu A is a natural active ingredient found in many plants such as Dioscorea villosa and Polygonatum multiflorum. It belongs to the steroidal saponin class of compounds. Huangjiangsu A is not cytotoxic, and treatment of HepG2 cells with it prior to exposure to H2O2 was effective in increasing cell viability in a concentration-dependent manner. In addition, 50 μM of Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin increased GSH levels and reduced intracellular ROS production, thereby counteracting H2O2-induced injury. Thus, Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation, and is expected to be a potential drug for the treatment of liver diseases[1-2].

HuangjiangSu A ?? ?? ? ???

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HuangjiangSu A ?? ??

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