ChemicalBook >?? ???? >Mc-Val-Cit-PABC-PNP
Mc-Val-Cit-PABC-PNP
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Mc-Val-Cit-PABC-PNP ??
- ?? ?
- 1034.5±65.0 °C(Predicted)
- ??
- 1.338±0.06 g/cm3(Predicted)
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- ???
- DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 13.24±0.70(Predicted)
- ??
- Off-white to light yellow
- InChIKey
- UQRQGHMQKAXOTE-DHIFEGFHSA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
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Mc-Val-Cit-PABC-PNP C??? ??, ??, ??
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Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.??
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.?? ??
Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.Mc-Val-Cit-PABC-PNP ?? ?? ? ???
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BIS(4-NITROPHENYL) CARBONATE
N-Succinimidyl 6-maleimidohexanoate
4-Aminobenzyl alcohol
MC-Val-Cit-PAB
?-??-PAB-OH
H-Cit-PABA
Fmoc-Cit-PABA
3-?????-???
4-Nitrophenyl chloroformate
FMOC-L-Valine
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L-????,N5-(a??????)-N2-[N-[(9H-????-9-????)????]-L-??]-
FMOC-VAL-OSU
FMoc-?-Cit-PAB
6-??? ????
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Mc-Val-Cit-PABC-PNP ?? ??
???( 244)?? ??
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