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?? ??:
1190848-23-7
???:
????????
???(??):
????????
???:
Fluorobexarotene
???(??):
Fluorobexarotene;Tropicamide Impurity 27;Fluorobexarotene, 10 mM in DMSO;2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid;Benzoic acid, 2-fluoro-4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-
CBNumber:
CB32535671
???:
C24H27FO2
??? ??:
366.47
MOL ??:
1190848-23-7.mol

???????? ??

?? ?
484.7±45.0 °C(Predicted)
??
1.082±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
<36.65mg/ml in DMSO; <9.16mg/ml in ethanol
?? ?? (pKa)
3.15±0.10(Predicted)
??? ??
Solid
??
White to off-white

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Fluorobexarotene is a retinoid X receptor (RXR) agonist, which facilitates β-amyloid clearance across blood-brain barrier; RXR activation has the potential to mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of Alzheimer’s disease.

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