PF-05212384
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PF-05212384 ??
- ???
- 226-227°C
- ??
- 1.364
- ?? ??
- Refrigerator
- ???
- ? ???DMSO
- ?? ?? (pKa)
- 13.97±0.70(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
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- ?? ? ???? ?? (GHS)
| HS ?? | 29349990 |
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| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
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PF-05212384 C??? ??, ??, ??
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Off-White Solid?? ???
This dual PI3K/mTOR (phosphoinositide-3-kinase and mammalian target of rapamycin) signal-transduction pathway inhibitor and antineoplastic agent (F.Wt. = 615.73; CAS 1197160-78-3); Solubility (25°C): 2 mg/mL DMSO, <1 mg/mL Water), also known as PF-05212384 and systematically as 1-(4- (4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino- 1,3,5-triazin-2-yl)phenyl)urea, inhibits PI3K-α, PI3K-γ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PKI-587 also inhibits mutant forms of PI3Kα, including the PI3Kα-H1047R and PI3Kα-E545K with IC50 of 0.6 nM and 0.6 nM, respectively.PF-05212384 ?? ?? ? ???
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PF-05212384 ?? ??
???( 173)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29857 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32222 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22855 | 58 |
PF-05212384 ?? ??:
PF-562271
Ketohexokinase inhibitor 1
PF-6274484
PF-9366
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
PF06869206
N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE
N,N'-Dimethyl-1,3-propanediamine
N,N-Dimethylbenzylamine
N,N-Dimethylbenzamide
N,N-Dimethylpropionamide
N-Methylpiperidine
Selumetinib
MK-2206 2HCl
IPI 145
PD 0332991 HCl
Rapamycin