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Hydroxypropyl methyl cellulose

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? (1) ?? : ? ?? 1g? ? 100mL? ?? ?? pH? 5.0～8.0??? ??

??(2) ?????????? : ? ?? 1g? ??? ?? ?????? 5mL? ?? ?? ??? ? ? 10?? ??? ????. ? ?? ?????? ???? ?????? ??. ??, ??????????[Aldrich 292087(1-Chloro-2-propanol 70%? 2-Chloro-1-propanol 25%? ???) ?? ?? ??? ?] 0.1g? ??? ?? ??????? ??? 100mL? ??, ? ? ???? ?? ??????? ???? 1mL? 6～25ng? ??????????? ????? ??? ?? ? ?????? ??. ???? ? ? ???? 1μL?? ??? ?????? ?????????? ????. ??? ? ????? ??(ng/mL)? ?? ????? ????? ???? ???? ????. ???? ?? ??????????? ????? ???? ?? ??? ??????? ???? ?? ?????????? ??? ?? ?, ? ?? 0.1ppm ????? ??.

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?????????? : DB-WAX(30m×0.53mm, 1μm) ?? ?? ??? ?

?????? ?? ? : ???????(ECD)

????????? : 200℃

??? ???? : 35℃?? 7?? ??? ? 8℃/min? ??? ??? ???? 200℃?? 5?? ????.

????????? : 230℃

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????????? ? : 1-???-2-????? ????? ? 11.7?, 2-???-1-????? ????? ? 12.5?? ??? ????.

??(3) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.

??(4) ??? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 1.0ppm ????? ??.

??(5) ?? : ? ??? ?????? ?? ??? ?, ? ?? 1.0ppm ????? ??.

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? (1) ? ??? ???(0.1→100)? ??? ??? ???? ???.

??(2) ? ??? ???(0.5→100) 5mL? 5% ????? ?? 5% ???????? 5mL? ???, ??? ??? ???.

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? ? ?? ? 65mg? ??? ?? ???(5mL ???? ???)? ?? ???? 65mg, ?????? 2.0mL ? ???????(??? ??? ?) 2.0mL? ?? ??? ?? ? ??? ??? ??. ???? 30?? ??? ?? ???? ???? 150℃, 20?? ??? ?? ????? ??? ?? ?? 40?? ????. 45?? ?? ?? ? ??? ??? ?? ??? 10mg ??? ?? ??? ?????? ??. ?? ???? 65mg, ?????? 2.0mL, ??????? 2.0mL? ???? ??? ??? ?? ? ??? ??? ?? ????????? 15μL? ?? ??? ??? ?? ?? ???? ?????? 45μL? ?? ??? ??? ??. ???? 30?? ??? ?? ?? ??? ?????? ??. ????? ???? 1μL? ?? ?????????? ???? ?? ?? ?? ????? ?????????? ??(%)? ???.

W_Sa : ?????? ??????? ?(mg)

W_Sb : ?????? ?????????? ?(mg)

Q_Sa, Q_Sb : ????? ??????? ????? ?? ?????? ? ?????????? ?????

Q_Ta, Q_Tb : ????? ??????? ????? ?? ?????? ? ?????????? ?????

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???????????? ? : ?????????? ???(Chromosorb WHP ?? ?? ??? ?)? 10% ???????? ?? ? ?? ?? ??? ?

???????? ?? ? : ???????(TCD) ?? ?????????(FID)

??????????? : 200℃

????? ???? : 50℃

??????????? : 200℃

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???????????? : ??? 0.25g? ??? ??? ο-????? 50mL? ??.

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? ? ??? ?????? ??? 50cps??? ???? 1.5% ??, 50cps??? ???? 3.0% ????? ??. ???「??????」? ???? (1)? ?? ????.

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Hydroxypropyl methyl cellulose is a propylene glycol ether of methylcellulose in which both hydroxypropyl and methyl groups are bound to the anhydrous glucose ring of cellulose by ether linkages. Hydroxypropyl methyl cellulose is synthesized from methyl cellulose by the action of alkali and propylene oxide. The resultant product is a water soluble ether derivative of cellulose containing both methoxy and hydroxypropyl groups. The degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent. White to off-white fibrous powder or granules. Soluble in water and some organic solvents. Insoluble in ethanol, the aqueous solution has surface activity, forms a thin film after drying, and undergoes a reversible transition from sol to gel in turn by heating and cooling.

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Hypromellose is an odorless and tasteless, white or creamy-white fibrous or granular powder. This product is soluble in water (10 mg/ml). However, it is very important to thoroughly disperse the particles in water with agitation before they will dissolve. Otherwise, they will lump and form a gelatinous membrane around the internal particles, preventing them from wetting completely. There are four dispersion techniques commonly used to prepare solutions of hydroxypropylmethylcellulose: dispersion in hot water, dry blending, dispersion in non-solvent medium, and dispersion of surface-treated powders.

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Hydroxypropyl methyl cellulose is used as an ophthalmic lubricant, an emulsifier and a thickening and suspending agent. It is widely used as an excipient in pharmaceutical formulations. It acts as a food additive. Its eye drops are known as artificial tears, which are used to relieve eye dryness and soreness. It finds applications in various fields as emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods. Pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems. In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.

Indications

Hydroxypropyl methylcellulose belongs to the group of medicines known as artificial tears. It is used to relieve dryness and irritation caused by reduced tear flow. It helps prevent damage to the eye in certain eye diseases. Hydroxypropyl methylcellulose may also be used to moisten hard contact lenses and artificial eyes. In addition, it may be used in certain eye examinations.

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A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with sodium hydroxide solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose. The alkali cellulose is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose. The fibrous reaction product is then purified and ground to a fine, uniform powder or granules. Hypromellose can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.

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Hydroxypropylmethylcelluloses are water soluble polymers derived from cellulose. They are typically used as thickeners, binders, film formers, and water retention agents. They also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. In addition, solutions of these polymers thermally gel.
These polymers are prepared by reacting wood or cotton cellulose fibers with propylene oxide and methyl chloride in the presence of caustic soda. This product has a methoxyl content of 28-30% and a hydroxypropoxyl content of 7-12%.

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Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug.
Major & minor side effects for Hydroxypropyl Methylcellulose
Blurred vision
Decrease/loss of vision
Eye pain
Excessive tearing of the eye
Redness in and around the eyes

Safety

Hypromellose is widely used as an excipient in oral, opthalmic, nasal, and topical pharmaceutical formulations. It is also used extensively in cosmetics and food products.
Hypromellose is generally regarded as a nontoxic and nonirritating material, although excessive oral consumption may have a laxative effect. The WHO has not specified an acceptable daily intake for hypromellose since the levels consumed were not considered to represent a hazard to health. In fact, high dosages of hypromellose are being investigated for treating various metabolic syndromes.
LD50 (mouse, IP): 5 g/kg(20) LD50 (rat, IP): 5.2 g/kg

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Hypromellose powder is a stable material, although it is hygroscopic after drying.
Solutions are stable at pH 3–11. Hypromellose undergoes a reversible sol–gel transformation upon heating and cooling, respectively. The gelation temperature is 50–90°C, depending upon the grade and concentration of material. For temperatures below the gelation temperature, viscosity of the solution decreases as temperature is increased. Beyond the gelation temperature, viscosity increases as temperature is increased.
Aqueous solutions are comparatively enzyme-resistant, providing good viscosity stability during long-term storage. However, aqueous solutions are liable to microbial spoilage and should be preserved with an antimicrobial preservative: when hypromellose is used as a viscosity-increasing agent in ophthalmic solutions, benzalkonium chloride is commonly used as the preservative. Aqueous solutions may also be sterilized by autoclaving; the coagulated polymer must be redispersed on cooling by shaking.
Hypromellose powder should be stored in a well-closed container, in a cool, dry place.

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Hypromellose is incompatible with some oxidizing agents. Since it is nonionic, hypromellose will not complex with metallic salts or ionic organics to form insoluble precipitates.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic and nasal preparations; oral capsules, suspensions, syrups, and tablets;topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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