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N-(2-?????)-5-????????-8-?????????

N-(2-?????)-5-????????-8-?????????
N-(2-?????)-5-????????-8-????????? ??? ???
?? ??:
1177141-67-1
???:
N-(2-?????)-5-????????-8-?????????
???(??):
N-(2-?????)-5-????????-8-?????????
???:
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
???(??):
CKI-7 2HCL;CKI-7 dihydrochlorid;CKI-7, 10 mM in DMSO;CKI-7 Dihydrochloride;CKI-7 (hydrochloride);N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride;N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
CBNumber:
CB31176497
???:
C11H14Cl3N3O2S
??? ??:
358.67176
MOL ??:
1177141-67-1.mol
MSDS ??:
SDS

N-(2-?????)-5-????????-8-????????? ??

???
187-189°C
?? ??
-20°C
???
H2O: >5mg/mL
??? ??
??
??? ??
??? ??
??
???? ?? ???
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H2O: >5mg/mL
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 25
????? 45
????(UN No.) UN 2811 6.1 / PGIII
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
??????:
P301+P310 ???? ?? ????(??)? ??? ????.
NFPA 704
0
2 0

N-(2-?????)-5-????????-8-????????? C??? ??, ??, ??

??? ??

Beige Solid

??

Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

N-(2-?????)-5-????????-8-????????? ?? ?? ? ???

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N-(2-?????)-5-????????-8-????????? ?? ??

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N-(2-?????)-5-????????-8-????????? ?? ??:

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