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Alosetron???
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Alosetron??? ??
- ???
- 288-291°C
- ?? ??
- 2-8°C
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- H2O: ??? ? ≥5mg/mL
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- H2O: ≥5mg/mL atwarmed
- CAS ??????
- 122852-69-1(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | T,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 25-36-52/53 | ||
| ????? | 26-45 | ||
| ????(UN No.) | UN 2811 6.1 / PGIII | ||
| WGK ?? | 3 | ||
| HS ?? | 2933790002 | ||
| ?? ?? ??? | 122852-69-1(Hazardous Substances Data) |
Alosetron??? C??? ??, ??, ??
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Lotronex (alosetron) was developed for the treatment of severe irritable bowel syndrome (IBS), and was approved for use by the US Food and Drug Administration (FDA) in 2000. Although Lotronex had a relatively high improvement rate in patients taking the drug for IBS, it was voluntarily pulled from the market by GlaxoWellcome that same year due to reports of severe adverse side effects, some resulting in death.In 2002, Lotronex was reapproved in a supplemental New Drug Application for use under more restrictive conditions. Now with a risk management program to be consulted prior to administration of the drug, Lotronex is designated to be prescribed only when its medical benefits outweigh the risks of toxic effects; women with severe diarrhea-predominant IBS are now the focal point of prescriptions for Lotronex.
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Alosetron hydrochloride is Crystalline Solid??
Alosetron hydrochloride is used in treatment of irritable bowel syndrome??
ChEBI: The hydrochloride salt of alosetron.????
The environmental fate and behavior of Lotronex is uncertain, as formal studies regarding its release into the environment are virtually nonexistent in the literature. Limited water solubility (61 mg ml-1) may lead to persistence in soils, and in sediment following aquatic release, although specific fates with regard to degradation, bioaccumulation, and transport are unknown.Alosetron??? ?? ?? ? ???
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