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BMS-345541 has been used:

• as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells
• as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts
• as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma?cells

Biochem/physiol Actions

BMS-345541 possesses anti-inflammatory properties. It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines. BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.

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ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
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InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
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TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65

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