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3-TRIMETHYLSILYL-2-PROPYN-1-OL

3-TRIMETHYLSILYL-2-PROPYN-1-OL ??? ???
?? ??:
5272-36-6
???:
3-TRIMETHYLSILYL-2-PROPYN-1-OL
???(??):
3-(triMethylsilyl)prop-2-yn-1-ol;3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL;3-TRIMETHYLSILANYL-PROP-2-YN-1-OL;3-Trimethylsilyl-2-propyn-1-ol,99%;2-Propyn-1-ol, 3-(trimethylsilyl)-;3-(Trimethylsilyl)propargyl alcohol 99%;DKSI027;TIMTEC-BB SBB009061;Trimethylsilylpropynol;3-Trimethylsilylpropargyl
CBNumber:
CB2482992
???:
C6H12OSi
??? ??:
128.24
MOL ??:
5272-36-6.mol
MSDS ??:
SDS

3-TRIMETHYLSILYL-2-PROPYN-1-OL ??

???
63.5-65.0 °C
?? ?
76 °C11 mm Hg(lit.)
??
0.865 g/mL at 25 °C(lit.)
???
n20/D 1.451(lit.)
???
152 °F
?? ??
Keep in dark place,Sealed in dry,Room Temperature
???
??(?? ???)
?? ?? (pKa)
13.71±0.10(Predicted)
??? ??
??
??
?? ???
Specific Gravity
0.865
???
?? ??? ????.
??
Moisture Sensitive
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN
1902505
InChIKey
ZVGCJDPEKKEYES-UHFFFAOYSA-N
CAS ??????
5272-36-6(CAS DataBase Reference)
NIST
3-Trimethylsilylpropargyl alcohol(5272-36-6)
EPA
2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 23-24/25-37/39-26
????(UN No.) 2810
WGK ?? 3
F ?????? 8-10
TSCA Yes
?? ?? 6.1
???? III
HS ?? 29319090
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H227 ??? ?? ??? ?? ?? 4 ?? P210, P280, P370+P378, P403+P235,P501
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P309 ?????? ?? ?? ?? ??
P310 ?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
NFPA 704
2
2 0

3-TRIMETHYLSILYL-2-PROPYN-1-OL C??? ??, ??, ??

??? ??

clear yellow liquid

??

Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

3-TRIMETHYLSILYL-2-PROPYN-1-OL ?? ?? ? ???

???

??[???(??????)??]?? Tetrahydro-2-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]-2H-Pyran PROPARGYLOXYTRIMETHYLSILANE TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 1-????????-3-?????????-2-? PHENYLETHYNYLMAGNESIUM BROMIDE 1-PHENYL-2-(TRIMETHYLSILYL)ACETYLENE ??????? ????????? ???? ???

?? ??

3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE 1-??????-1-?? 3-TRIMETHYLSILYLPROPYNAL 3-Iodo-1-trimethylsilylpropyne

3-TRIMETHYLSILYL-2-PROPYN-1-OL ?? ??

???( 227)?? ??
??? ?? ??? ?? ?? ? ??
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3-TRIMETHYLSILYL-2-PROPYN-1-OL ?? ??:

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