3-???-1-????
|
|
3-???-1-???? ??
- ???
- -20 °C
- ?? ?
- 160-162 °C(lit.)
- ??
- 1.131 g/mL at 25 °C(lit.)
- ???
- n
20/D 1.445(lit.)
- ???
- 164 °F
- ?? ??
- 0-6°C
- ???
- 50g/l(?? ??)
- ??? ??
- ??
- ?? ?? (pKa)
- 14.73±0.10(Predicted)
- Specific Gravity
- 1.14
- ??
- ??~???? ???
- ??????(pH)
- 3-4 (100g/l, H2O, 20℃)
- ???
- 300 g/L (20 ºC)
- BRN
- 773655
- ?? ??
- No exposure limit is set. A TLV-TWA air value of 100 ppm (approximately 400 mg/m3) is suggested for this compound.
- ???
- ??? ?????? ?? ?????. ?? ??. ?? ???? ???? ????.
- InChIKey
- LAMUXTNQCICZQX-UHFFFAOYSA-N
- CAS ??????
- 627-30-5(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26-36-36/37/39 | ||
| ????(UN No.) | UN 2849 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | UA8930000 | ||
| TSCA | Yes | ||
| ?? ?? | 6.1 | ||
| ???? | III | ||
| HS ?? | 29055910 | ||
| ???? ?? | KE-05877 |
3-???-1-???? C??? ??, ??, ??
??? ??
Colorless to pale-yellow liquid; characteristic odor. Soluble in water, alcohols, and ethers; insoluble in hydrocarbons. Combustible.??
3-Chloro-1-propanol is used in organicsynthesis to produce cyclopropane andtrimethylene oxide. It is an intermediate inthe synthesis of pharmaceuticals, agrochemicals, antiseptic agents, and dyes. It is an inhibitor of triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase.?? ??
3-Chloro-1-propanol is synthesized by the reaction of 1, 3-propanediol and hydrochloric acid, using benzene sulfonic acid as the catalyst.Reaction: 250 g of trimethylene glycol are shaken with 450 g of sulfur chloride, the mixture becoming warm, sulfur dioxide being rapidly evolved, and sulfur deposited. This reaction continues for 1 hours without heating, whereafter the mixture is heated for a further 6 hours on the water-bath and then for 30 min, over a free flame. When no more sulfur dioxide is evolved, the mixture is allowed to cool, then extracted several times with ether. The sulfur is washed with ether, and the united ethereal layers are shaken with sodium carbonate solution to remove sulfur dioxide, dried over sodium sulfate, and freed from ether. The residue is fractionated and the fraction of b.p. 140-180° C is redistilled, giving 60% (160 g) of 3-chloro-1-propanol, b.p. 160-164°C/760 mm, 60-64° C/10 mm.
J. Amer. Chem. Soc, 38, 2481 (1916)
J. Chem. Soc, 1928, 2439
?? ??
3-Chloro-1-propanol appears as a colorless liquid with a mild odor. Slightly denser than water. Toxic by ingestion and inhalation . Flash point 270°F. Used to make plastics, resins and other chemicals.?? ???
3-Chloro-1-propanol may be sensitive to prolonged exposure to light. 3-Chloro-1-propanol may react with oxidizing agents. .????
3-Chloro-1-propanol also know as Trimethylene chlorohydrin, is a moderatelytoxic compound. Skin contact can cause irritation.Ingestion can result in CNSdepression, muscle contraction, gastrointesti nal pain, and ulceration or stomach bleed ing. High dosage can cause liver injury. Thetoxicity of this compound, however, is lesssevere than that of its isomer, propylene β-chlorohydrin.LD50 value, oral (mice): 2300 mg/kg
????
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.Safety Profile
Moderately toxic by ingestion. Mutation data reported. Chloropropanols have mutagenic and carcinogenic properties. The 3-monochloropropanol (3-MCPD) is the main chloropropanol found in hydrolyzates of vegetable protein (HVP) made by acid hydrolysis.??? ??
Trimethylene chlorohydrin is burned in achemical incinerator equipped with an afterburner and scrubber.3-???-1-???? ?? ?? ? ???
???
?? ??
9-(3-(CIS-3 5-DIMETHYL-1-PIPERAZINYL)-
??-????????
1,5-???????[4.3.0]?-5-?
Mivacurium chloride
4-(3-MORPHOLINOPROPOXY)-3,5-DICHLOROBENZENAMINE
???? ?????
9-??????
?????????
?????????
3-Chloropropyl acetate
1-???-2-????
1-???-3-(??-P-?????)???
3-(3-HYDROXY-PROPYLAMINO)-PROPAN-1-OL
3-???????
1-(3-????????)-4-??????
3-???????-1-OL
3-Phenoxy-1-propanol
1-(3-????????)-1H-????
???????n-?????
3-(2-methyl-1H-imidazol-1-yl)propan-1-ol(SALTDATA: HCl)
3-???-1-???? ?? ??
???( 395)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10244 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8833 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86-13288715578 +86-13288715578 |
sales@hbmojin.com | China | 12765 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 |
faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 +86-13131129325 |
sales1@chuanghaibio.com | China | 5255 | 58 |
| Taixing Foreign Trade Nanjing Co., Ltd. | +86-025-83346564; +8613182976929 |
sales@tx-chem.com | China | 123 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21624 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29856 | 58 |