PHORBOL 12-MYRISTATE 13-ACETATE
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PHORBOL 12-MYRISTATE 13-ACETATE ??
- ???
- 65-79oC
- ?? ?
- 571.87°C (rough estimate)
- ??
- 1.17±0.1 g/cm3 (20 ºC 760 Torr)
- ???
- 1.4900 (estimate)
- ?? ??
- -20°C
- ???
- DMSO: DMSO ??? ?? 6?? ?? '20'C?? ??? ??? ??? ? ????.
- ?? ?? (pKa)
- 11.19±0.70(Predicted)
- ??? ??
- ?? ??? ??
- ??
- ????? ?? ?????
- ???
- ???? ?? ? ?? DMSO, ?????, ??? ?? ???, ???, ?? ?????, DMF ?? ??????? ? ????. ?? ???.
- ??
- Light Sensitive
- BRN
- 2407201
- ???
- ??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 2?? ?? ??? ? ????.
- InChIKey
- PHEDXBVPIONUQT-RGYGYFBISA-N
- CAS ??????
- 16561-29-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 38-36/37/38 | ||
| ????? | 36/37-26 | ||
| ????(UN No.) | 2928 | ||
| WGK ?? | 3 | ||
| RTECS ?? | QH4377000 | ||
| F ?????? | 8-10 | ||
| ?? ?? | 6.1(a) | ||
| ???? | II | ||
| HS ?? | 29153900 | ||
| ?? ?? ??? | 16561-29-8(Hazardous Substances Data) | ||
| ?? | Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events. |
PHORBOL 12-MYRISTATE 13-ACETATE C??? ??, ??, ??
??? ??
white to off-white solid??
4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.?? ??
White crystals.??? ?? ??
Practically water insoluble.?? ???
PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .????
Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.???? ??
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.PHORBOL 12-MYRISTATE 13-ACETATE ?? ?? ? ???
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?? ??
PHORBOL 12-MYRISTATE 13-ACETATE ?? ??
???( 267)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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PHORBOL 12-MYRISTATE 13-ACETATE ?? ??:
1,2-DIOCTANOYL-SN-GLYCEROL
Prostratin, PKC activator
1-OLEOYL-2-ACETYL-SN-GLYCEROL
(-)-INDOLACTAM V
INGENOL 3,20-DIBENZOATE
(+)-7-OCTYLINDOLACTAM V
FTT
PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL
4Α-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL 13-ACETATE
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%,4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL,4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL-12-MYRISTATE-13-ACETATE, [20-3H(N)]
PHORBOL 12-MYRISTATE-13-ACETATE-4-O-METHYL ETHER,PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA,PHORBOL 12-MYRISTATE-13-ACETATE-4-O- &
PHORBOL 16-HYDROXY 12-PALMITATE 13-ACETATE
Phorbol 12-myristate 13-acetate diester
12-O-hexadecanoylphorbol-13-acetate
PHORBOL-12-MYRISTATE-13-ACETATE = PMA