CK 869;CK-869;CS-2870;CK-0157869;CK-869, 10 mM in DMSO;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one;CK869, Actin-related protein 2/3 (Arp2/3) complex inhibitor;4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
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CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
