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4,4'-??????????????

4,4'-??????????????
4,4'-?????????????? ??? ???
?? ??:
27469-60-9
???:
4,4'-??????????????
???(??):
4,4'-??????????????
???:
4,4'-Difluorobenzhydrylpiperazine
???(??):
1-Bis(4-fL;1-(4,4'TIMTEC-BB SBB002996;Flunarizine Impurity A;Flunarizine EP Impurity A;1-[Bis(4-Fluorophenyl)methyl]p;4,4-DIFLUOROBENZHYDRYLPIPERAZINE;4,4-Difluorobenzhydrolpiperazine;4,4'-Difluorobenzhydrylpiperazine;4,4'-DIFLUOROBENZHYDRYL PIPERAZINE
CBNumber:
CB2161725
???:
C17H18F2N2
??? ??:
288.33
MOL ??:
27469-60-9.mol

4,4'-?????????????? ??

???
88-92 °C(lit.)
?? ?
130 °C
??
1.1462 (estimate)
???
0.001-0.003Pa at 20-25℃
?? ??
Keep in dark place,Inert atmosphere,Room temperature
???
soluble in Methanol,Toluene
?? ?? (pKa)
9.00±0.10(Predicted)
??? ??
??? ??
??
???? ?????
???
0.34g/L(20℃)
BRN
620754
???
???
LogP
3.3-3.5 at pH7-11
CAS ??????
27469-60-9(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 25-36/37/38
????? 26-45-36/37/39
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
F ?????? 10-34
?? ?? ?? Toxic
?? ?? IRRITANT
?? ?? 6.1
???? III
HS ?? 29335990
???? ?? KE-03157
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
3 0

4,4'-?????????????? MSDS


1-(4,4'-Difluorobenzhydryl)piperazine

4,4'-?????????????? C??? ??, ??, ??

??? ??

white to yellow crystalline powder

??

1-Bis(4-fluorophenyl)methyl piperazine may be used to synthesize 1-[bis(4-fluorophenyl)methyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine and (R, S) 3-[4-(bis(4-fluorophenyl)methyl)piperazin-1-yl]dihydrofuran-2(3H)-one.

?? ??

1-Bis(4-fluorophenyl)methyl piperazine is formed during the synthesis of flunarizine. Its crystals exhibits monoclinic crystal system and space group P21/c.

4,4'-?????????????? ?? ?? ? ???

???

?? ??

Flunarizine Lomerizine hydrochloride

4,4'-?????????????? ?? ??

???( 301)?? ??
??? ?? ??? ?? ?? ? ??
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4,4'-?????????????? ?? ??:

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