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(R,S)-????

(R,S)-???? ??? ???

?? ??:: 2743-90-0

???:: (R,S)-????

???(??):: (R,S)-????

???:: (R,S)-ANATABINE

???(??):: D,L-ANATABINE;rac-Anatabine;(R,S)-ANATABINE;Nicotine USP RC A;ANATABINE, (+/-)-(RG);1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Nicotine EP Impurity A as Racemate;1,2,3,6-Tetrahydro-2,3'-bipyridine;Anatabine, froM Nicotiana tabacuM L.;2,3'-Bipyridine, 1,2,3,6-tetrahydro-

CBNumber:: CB1382628

???:: C10H12N2

??? ??:: 160.22

MOL ??:: 2743-90-0.mol

MSDS ??:: SDS

?? ?? 114

(R,S)-???? ??

?? ?: 136

??: 1.045±0.06 g/cm3(Predicted)

?? ??: Amber Vial, Refrigerator, Under Inert Atmosphere

???: ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide

??? ??: solution in ethanol.

?? ?? (pKa): 8.84±0.40(Predicted)

??: Light yellow to yellow

???: ???, ???

CAS ??????: 2743-90-0

?? ? ?? ??
?? ? ???? ?? (GHS)

?? ???? ??	25-36
?????	24/25
????(UN No.)	2810
?? ??	IRRITANT
HS ??	29399990

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H301	??? ???	?? ?? ?? - ??	?? 3	??		P264, P270, P301+P310, P321, P330,P405, P501
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??		P264, P280, P305+P351+P338,P337+P313P

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P280	????/???/???/?????? ?????.
P301+P310	???? ?? ????(??)? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.

(R,S)-???? C??? ??, ??, ??

??

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

??? ??

Light Yellow Oil

??

(R,S)-Anatabine is a metabolite of Nicotine (N412420).

(R,S)-???? ?? ?? ? ???

???

?? ??

(R,S)-???? ?? ??

???( 114)?? ??

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(R,S)-???? ?? ??:

Neotuberostemonine (+/-)-ANABASINE 2,3'-Bipyridine (R,S)-ANATABINE-2,4,5,6-D4 S-(-)-ANATABINE ANATABINE (R,S)-N-NITROSOANATABINE (R,S)-N-NITROSOANATABINE-2,4,5,6-D4 1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-Anatabine-d4 5,5'-DIMETHYL-6,6'-DIPHENYL-1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE 2-CHLORO-1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-ANATABINE BITARTRATE (3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)(PHENYL)METHANONE (R,S)-ANATABINE

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