ChemicalBook >?? ???? >(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-???
(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-???
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(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-??? ??
- ?? ??
- Inert atmosphere,Store in freezer, under -20°C
- CAS ??????
- 608141-43-1
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- ?? ? ???? ?? (GHS)
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(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-??? C??? ??, ??, ??
Synthesis
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-??? ?? ?? ? ???
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(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-??? ?? ??
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(S)-1-(3-???-4-?????)-2-(?????)????N-???-L-??? ?? ??:
Apremilast Impurity 9
Apremilast Impurity 2
APST-ZA
(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
3-acetamidophthalic acid
Apremilast Impurity E
Apremilast Impurity 1
Apremilast Impurity 13
Apremilast Impurity 8
Apremilast Impurity 1/2
Apremilast
ApreMilast-d5
Apremilast impurity 15
Apremilast Impurity F
Apremilast Impurity C
[[p-(2-methoxyethyl)phenoxy]methyl]oxirane
Apremilast Impurity 10