???? ?????
|
|
???? ????? ??
- ???
- 176-1780C
- ?? ??
- 2-8°C
- ???
- DMSO: ~1mg/mL
- ??? ??
- ??
- ??
- ???
- Merck
- 14,6495
- ???
- ??? ?? ?????? 1? ?? ??????. ??? ?? ??? ??? -20°C?? ?? 1?? ?? ??? ? ????.
- InChIKey
- AIKVCUNQWYTVTO-UHFFFAOYSA-N
- CAS ??????
- 54527-84-3(CAS DataBase Reference)
??
- ?? ? ?? ??
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 23/24/25 | ||
| ????? | 36/37/39-45 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | US7972100 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 2933399090 | ||
| ?? | LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado) | ||
| ???? ?? | KE-10623 |
???? ????? C??? ??, ??, ??
??
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).??? ??
Yellow Solid??
Dihydropyridine calcium channel blocker. Antianginal; antihypertensive?? ??
Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an???? ????? ?? ?? ? ???
???
?? ??
???? ????? ?? ??
???( 347)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 |
faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 |
mina@chuanghaibio.com | China | 18128 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 485 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21623 | 55 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5906 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29807 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86-13288715578 +86-13288715578 |
sales@hbmojin.com | China | 12765 | 58 |