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9013-90-5
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LACTALBUMIN
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LACTALBUMIN;EC 2.4.1.22;Lactalbumins;ALBUMIN (MILK);ALBUMIN LACTIC;ALPHA-LACTALBUMIN;BOVINEALPHA-LACTALBUMIN;COW'SMILKALPHA-LACTALBUMIN
CBNumber:
CB0309035
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n.a.
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0
MOL ??:
Mol file

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2-8°C
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CAS ??????
9013-90-5
EPA
Lactalbumins (9013-90-5)

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WGK ?? 3
F ?????? 10

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α-Lactalbumin was used in a cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome.

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α-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.

Biochem/physiol Actions

α-Lactalbumin consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex. The mature protein consists of 123 amino acid residues (14 kDa), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four a-helices and a triple stranded antiparallel β-sheet.

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