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??????-d3
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176652-07-6
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??????-d3
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??????-d3
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Artemisinin-d3
???(??):
QHS-d3;Artemisine-d3;Arteannuin-d3;Artemisinin-d3;Huanghuahaosu-d3;[2H3]-Artemisinin;(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6-dimethyl-9-(methyl-d3)-3,12-epox-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-(methyl-d3)-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]- (9CI);3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-(methyl-d3)-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]- (9CI)
CBNumber:
CB01176133
???:
C15H22O5
??? ??:
282.33218
MOL ??:
176652-07-6.mol

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156-157°C
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-20°C Freezer
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DMSO: Slightly soluble,Methanol: Slightly soluble
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CAS ??????
176652-07-6
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????(GHS): GHS hazard pictogramsGHS hazard pictograms
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H242 ???? ??? ??? ? ?? ????? ?? ? ???;?????? ?? C, D,?? E, F
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??		 GHS hazard pictograms P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
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P210 ?·???·??·????? ????? - ?? ???.
P220 ?? ??? ??? ????? ?????.
P234 ??? ???? ?????.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P391 ???? ????.
P410 ????? ????.
P411+P235 ???? ?? ????? ?? ? (80)℃? ?? ??? ?????. ???? ?????.
P420 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
3
0 0

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Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.

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Crystalline Solid

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Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial

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