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4-Amidinophenylmethanesulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride ??? ???
?? ??:
74938-88-8
???:
4-Amidinophenylmethanesulfonyl fluoride hydrochloride
???(??):
4-APMSF;P-APMSF;APMSF HCL;Nsc727369;uoride hydrochL;4-AmidinophenyL;APMSF HYDROCHLORIDE;4-Amidinophenylmetha;P-APMSF, HYDROCHLORIDE;p-APMSF, Hydrochloride
CBNumber:
CB0113452
???:
C8H10ClFN2O2S
??? ??:
252.69
MOL ??:
74938-88-8.mol
MSDS ??:
SDS

4-Amidinophenylmethanesulfonyl fluoride hydrochloride ??

???
~205 °C (dec.)
?? ??
-20°C
???
H2O: 50 mM '20°C?? ???? ??????. ??? = pH 7.0 ?? ????? 6?.
??? ??
?? ??
??
white
???
water: 25mg/mL
BRN
9083148
InChIKey
KHLLRHIUKOJXLL-UHFFFAOYSA-N
CAS ??????
74938-88-8(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20/21/22-36/37/38
????? 22-24/25-36-26
WGK ?? 3
F ?????? 10-21
HS ?? 29252900
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H314 ??? ?? ??? ?? ??? ??? ????? ?? ????? ?? 1A, B, C ?? GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P330+P331 ???? ?? ?????. ??? ?? ?? ???.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.

4-Amidinophenylmethanesulfonyl fluoride hydrochloride C??? ??, ??, ??

??

p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

Biochem/physiol Actions

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

4-Amidinophenylmethanesulfonyl fluoride hydrochloride ?? ?? ? ???

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4-Amidinophenylmethanesulfonyl fluoride hydrochloride ?? ??

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4-Amidinophenylmethanesulfonyl fluoride hydrochloride ?? ??:

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