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クロルヘキシジン

クロルヘキシジン 化學(xué)構(gòu)造式
55-56-1
CAS番號.
55-56-1
化學(xué)名:
クロルヘキシジン
別名:
1,1'-ヘキサメチレンビス[5-(p-クロロフェニル)ビグアニド];N',N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン;N,N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン;ツブリシド;クロルヘキシジン;クロロヘクス;1,1'-(1,6-ヘキサンジイル)ビス[5-(4-クロロフェニル)ビグアニド];ノルバサン;1,1'-ヘキサメチレンビス[5-(4-クロロフェニル)ビグアニド];クロロヘックス;ロテルセプト;1,1'-(ヘキサン-1,6-ジイル)ビス[5-(4-クロロフェニル)ビグアニド];クロロヘキシジン;N,N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンビス(イミドアミド);ヘキサドール;ステリロン;クロロヘキス;ソレトール;フィメイル;クロルヘキシジン 塩化物
英語名:
Chlorhexidine
英語別名:
CHLORHEXIDINE BASE;CHLOROHEXIDINE;chlorhexidin;sterilon;fimeil;soretol;hexadol;nolvasan;tubulicid;rotersept
CBNumber:
CB4732251
化學(xué)式:
C22H30Cl2N10
分子量:
505.45
MOL File:
55-56-1.mol
MSDS File:
SDS

クロルヘキシジン 物理性質(zhì)

融點 :
134-136 °C (lit.)
沸點 :
641.45°C (rough estimate)
比重(密度) :
1.1555 (rough estimate)
屈折率 :
1.6300 (estimate)
貯蔵溫度 :
2-8°C
溶解性:
水: 可溶0.08% at 20°C
酸解離定數(shù)(Pka):
pKa 10.78 (Uncertain)
外見 :
Solid
色:
White to off-white
水溶解度 :
0.08g/100mL(20℃)
Merck :
13,2108
BRN :
2826432
安定性::
安定。強力な酸化剤とは相容れない。
InChIKey:
GHXZTYHSJHQHIJ-UHFFFAOYSA-N
LogP:
0.080
CAS データベース:
55-56-1(CAS DataBase Reference)
EPAの化學(xué)物質(zhì)情報:
Chlorhexidine (55-56-1)
安全性情報
  • リスクと安全性に関する聲明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,N
Rフレーズ  36/37/38-43-51/53-50/53
Sフレーズ  26-36/37-60-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS 番號 DU1925000
10-34
國連危険物分類  9
容器等級  III
HSコード  29215900
有毒物質(zhì)データの 55-56-1(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 5000 mg/kg
絵表示(GHS) GHS hazard pictogramsGHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 GHS hazard pictograms P280, P305+P351+P338, P310
H410 長期的影響により水生生物に非常に強い毒性 水生環(huán)境有害性、慢性毒性 1 警告 GHS hazard pictograms P273, P391, P501
注意書き
P273 環(huán)境への放出を避けること。
P280 保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。
P305+P351+P338 眼に入った場合:水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P391 漏出物を回収すること。
P501 內(nèi)容物/容器を...に廃棄すること。

クロルヘキシジン 価格 もっと(13)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
富士フイルム和光純薬株式會社(wako) W01W0103-2029 クロルヘキシジン標(biāo)準(zhǔn)品 98.0+% (HPLC)
Chlorhexidine Standard 98.0+% (HPLC)
55-56-1 200mg ¥12200 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01MPB02191358 クロルヘキシジン
Chlorhexidine, FREE BASE
55-56-1 5g ¥12900 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01MPB02191358 クロルヘキシジン
Chlorhexidine, FREE BASE
55-56-1 25g ¥19800 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) 46102-1A
Chlorhexidine
55-56-1 1g ¥15730 2024-07-01 購入
Sigma-Aldrich Japan 282227 クロルヘキシジン ≥99.5%
Chlorhexidine ≥99.5%
55-56-1 1g ¥21200 2024-03-01 購入

クロルヘキシジン MSDS


Hexamethylenebis(5-(4-chlorophenyl)biguanide)

クロルヘキシジン 化學(xué)特性,用途語,生産方法

外観

白色?ほとんど白色, 結(jié)晶性粉末?粉末

定義

本品は、次の化學(xué)式で表される芳香族化合物である。

溶解性

N ,N -ジメチルホルムアミドに溶け、水、エタノール及びアセトンにほとんど溶けない。

用途

防腐剤、消毒薬

化粧品の成分用途

防腐剤、口腔ケア剤、殺菌剤

効能

殺菌消毒薬, 細(xì)胞膜機能阻害薬

説明

Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action.
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has a LD-50 orally in mice as a diacetate at 2gm./kg. In digluconate form the LD-50 is 1800 gm./kg.

化學(xué)的特性

Chlorhexidine occurs as an odorless, bitter tasting, white crystalline powder.

使用

Chlorhexidine is an antibacterial used for numerous applications. It is a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate. Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system.
  1. Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material.
  2. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. it is used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry.
  3. Hydrogenolysis of benzyl-nitrogen bonds.
  4. Bacteriostatic;Detergent.

定義

ChEBI: A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

調(diào)製方法

Chlorhexidine may be prepared either by condensation of polymethylene bisdicyandiamide with 4-chloroaniline hydrochloride or by condensation of 4-chlorophenyl dicyandiamine with hexamethylenediamine dihydrochloride. Chlorhexidine may also be synthesized from a series of biguanides.

適応癥

This topical antiseptic product acts rapidly but, like hexachlorophene, persists on the skin to give a cumulative, continuing antibacterial effect. Like iodophors and alcohol, it is active against gram-positive and gram-negative bacteria, including P. aeruginosa, as well as common yeasts and fungi. It does not lose effectiveness in the presence of whole blood. Many consider it the antiseptic of choice for skin cleansing and surgical scrubs. Contact allergy is not uncommon. Chlorhexidine should not be used near the eyes or mucosal surfaces, because it may cause irritation or even anaphylaxis.

主な応用

Chlorhexidine is an important medical, dental and pharmaceutical antiseptic, disinfectant and preservative. It is bactericida and fungicidalsy but does not kill bacterial spores or mycobacteria, although it inhibits growth. It has a low order of activity against viruses, but high concentrations are effective in killing cysts of Acanthamoeba spp., organisms of potential clinical significance to the wearers of contact lenses. Properties Chlorhexidine is a bisbiguanide which is available as the acetate (diacetate), hydrochloride and gluconate salts. These are stable in solution and can be autoclaved although small amounts of chloroaniline are released.” As a cationic agent, chlorhexidine is incompatible with anionic surfactants and its antimicrobial activity is reduced in the presence of non-ionic surface-active agents. Activity is also reduced or abolished by phospholipids (a factor of significance in neutralizing chlorhexidine activity during the performance of biocidal tests) and by organic matter including serum. Some of these aspects have been well documented in the recent comprehensive paper of Nicoletti et al.” They also point out that the efficacy of chlorhexidine is influenced by formulation components and by the composition of the culture medium in which minimum inhibitory concentrations (MICs) are determined.

一般的な説明

Effect of the chlorhexidine:hydroxypropyl-β-cyclodextrin inclusion compound on in vitro slabs of bovine dentine has been investigated.

応用例(製薬)

Chlorhexidine salts are widely used in pharmaceutical formulations in Europe and Japan for their antimicrobial properties. Although mainly used as disinfectants, chlorhexidine salts are also used as antimicrobial preservatives.
As excipients, chlorhexidine salts are mainly used for the preservation of eye-drops at a concentration of 0.01% w/v; generally the acetate or gluconate salt is used for this purpose. Solutions containing 0.002–0.006% w/v chlorhexidine gluconate have also been used for the disinfection of hydrophilic contact lenses.
For skin disinfection, chlorhexidine has been formulated as a 0.5% w/v solution in 70% v/v ethanol and, in conjunction with detergents, as a 4% w/v surgical scrub. Chlorhexidine salts may also be used in topical antiseptic creams, mouthwashes, dental gels, and in urology for catheter sterilization and bladder irrigation.
Chlorhexidine salts have additionally been used as constituents of medicated dressings, dusting powders, sprays, and creams.

臨床応用

Chlorhexidine is a biguanide topical antiseptic and disinfectant with broad antimicrobial efficacy. It is increasingly being used as an aseptic but it is also gaining use as a biocidal ingredient in shampoos, conditioners, hair dyes, sunscreens, toothpastes, mouthwashes (Corsodyl), wet wipes (also for babies), eye creams, antiwrinkle creams, moisturizers, contact lens solutions, and instillation gels for urinary catheters.Urticaria following application to intact skin or mucosae, in some cases accompanied by dyspnea, angioedema, syncope, or anaphylaxis has been described via the mucosal route at much lower concentration than elsewhere, generally as low as 0.05%.

安全性プロファイル

Poison by intraperitoneal andintravenous routes. Mildly toxic by ingestion.Experimental reproductive effects. A human skin irritant.Mutation data reported. When heated to decomposition itemits very toxic fumes of Cl- and NOx.

不和合性

Chlorhexidine salts are cationic in solution and are therefore incompatible with soaps and other anionic materials. Chlorhexidine salts are compatible with most cationic and nonionic surfactants, but in high concentrations of surfactant chlorhexidine activity can be substantially reduced owing to micellar binding.
Chlorhexidine salts of low aqueous solubility are formed and may precipitate from chlorhexidine solutions of concentration greater than 0.05% w/v, when in the presence of inorganic acids, certain organic acids, and salts (e.g. benzoates, bicarbonates, borates, carbonates, chlorides, citrates, iodides, nitrates, phosphates, and sulfates). At chlorhexidine concentrations below 0.01% w/v precipitation is less likely to occur.
In hard water, insoluble salts may form owing to interaction with calcium and magnesium cations. Solubility may be enhanced by the inclusion of surfactants such as cetrimide.
Other substances incompatible with chlorhexidine salts include viscous materials such as acacia, sodium alginate, sodium carboxymethylcellulose, starch, and tragacanth. Also incompatible are brilliant green, chloramphenicol, copper sulfate, fluorescein sodium, formaldehyde, silver nitrate, and zinc sulfate.
Interaction has been reported between chlorhexidine gluconate and the hydrogel poly(2-hydroxyethyl methacrylate), which is a component of some hydrophilic contact lenses.

規(guī)制狀況(Regulatory Status)

Chlorhexidine salts are included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

クロルヘキシジン 上流と下流の製品情報

原材料

準(zhǔn)備製品


クロルヘキシジン 生産企業(yè)

Global( 570)Suppliers
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Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd
+86-15531157085; +8615531157085
abby@chuanghaibio.com China 8804 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12767 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325 +86-13131129325
sales1@chuanghaibio.com China 5255 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20212 58
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+86-18353166132 +86-18353166132
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Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
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Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21624 55
Panjin Jiahe Shengshi Medical Technology Co., Ltd.
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jiahe@jhssw.com CHINA 4 55

クロルヘキシジン  スペクトルデータ(1HNMR、IR)


55-56-1(クロルヘキシジン)キーワード:


  • 55-56-1
  • 1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguanid
  • 1,6-bis(5-(p-chlorophenyl)biguandino)hexane
  • 1,6-bis(p-chlorophenyldiguanido)hexane
  • 1,6-di(4’-chlorophenyldiguanido)hexane
  • 2,4,11,13-tetraazatetradecanediimidamide,n,n’’-bis(4-chlorophenyl)-3,12-diim
  • fimeil
  • hexadol
  • nolvasan
  • rotersept
  • soretol
  • tubulicid
  • 1,1'-HEXAMETHYLENEBIS[5-(4-CHLOROPHENYL)BIGUANIDE]
  • CHLORHEXIDINE
  • LABOTEST-BB LT00440966
  • hexamethylenebis(5-(4-chlorophenyl)biguanide)
  • bis(5-(p-chlorophenyl)biguanidinio)hexane
  • n,n'-bis(4-chlorophenyl)-3,12-diimino-tetraazatetradecanediimidamide
  • 5,5-bis(4-chlorophenyl)-1,1-hexamethylenedibiguanide
  • CHLORHEXIDINE, 99.5+%
  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N-bis(4-chlorophenyl)-3,12-diimino-
  • 11HEXAMETHYLENEBIS5PARACHLOROPHENYLBIGUANIDE
  • chlorhexidine 55-56-1
  • Chlorhexidine (base and/or unspecified salts)
  • 1,6-Bis[5-(p-chlorophenyl)biguanidino]hexane
  • 1,6-Di(N-p-chlorophenylbiguanidino)hexane
  • Bis(p-chlorophenyldiguanido)hexane
  • MPB Chlorhexidine
  • Chlorhexidine (free base)
  • Chlorhexidine,1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]
  • Chlorhexidine (200 mg)
  • 1,1'-ヘキサメチレンビス[5-(p-クロロフェニル)ビグアニド]
  • N',N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン
  • N,N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン
  • ツブリシド
  • クロルヘキシジン
  • クロロヘクス
  • 1,1'-(1,6-ヘキサンジイル)ビス[5-(4-クロロフェニル)ビグアニド]
  • ノルバサン
  • 1,1'-ヘキサメチレンビス[5-(4-クロロフェニル)ビグアニド]
  • クロロヘックス
  • ロテルセプト
  • 1,1'-(ヘキサン-1,6-ジイル)ビス[5-(4-クロロフェニル)ビグアニド]
  • クロロヘキシジン
  • N,N''-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンビス(イミドアミド)
  • ヘキサドール
  • ステリロン
  • クロロヘキス
  • ソレトール
  • フィメイル
  • クロルヘキシジン 塩化物
  • 1,1’ヘキサメチレンビス(5(pクロロフェニル)ビグアナイド)
  • 1,1’-ヘキサメチレンビス(5-(p-クロロフェニル)ビグアナイド)
  • クロルヘキシジン標(biāo)準(zhǔn)品
  • N,N′′-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン
  • 1,1′-(ヘキサン-1,6-ジイル)ビス[5-(4-クロロフェニル)ビグアニド]
  • 1,1′-ヘキサメチレンビス[5-(p-クロロフェニル)ビグアニド]
  • 1,1′-(1,6-ヘキサンジイル)ビス[5-(4-クロロフェニル)ビグアニド]
  • N-(4-クロロフェニル)-1-{N'-[6-(N-{[N'-(4-クロロフェニル)カルバムイミドアミド]メタンイミドイル}アミノ)ヘキシル]カルバムイミドアミド}メタンイミドアミド
  • N,N′′-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンビス(イミドアミド)
  • α,α′-(1,6-ヘキサンジイルビスイミノ)ビス[[3-(4-クロロフェニル)グアニジノ]メタンイミン]
  • 1,1′-ヘキサメチレンビス[5-(4-クロロフェニル)ビグアニド]
  • N,N′-(1,3,12,14-テトライミノ-2,4,11,13-テトラアザテトラデカン-1,14-ジイル)ビス(4-クロロアニリン)
  • N′,N′′-ビス(4-クロロフェニル)-3,12-ジイミノ-2,4,11,13-テトラアザテトラデカンジアミジン
  • 1,1′-(ヘキサメチレン)ビス[5-(4-クロロフェニル)-2,4-ビスイミノ-1,3,5-トリアザペンタン]
  • 口腔用薬
  • 殺菌薬
  • 外皮作用薬
  • その他の有機分析用の標(biāo)準(zhǔn)物質(zhì)
  • 生活関係標(biāo)準(zhǔn)物質(zhì)
  • 食料品
  • 有機標(biāo)準(zhǔn)物質(zhì)
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