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ChemicalBook >> CAS DataBase List >>1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-

CAS No.
2407829-65-4
Chemical Name:
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
Synonyms
WUN-29654;CRBN modulator-1;CRBN modulator-1, 10 mM in DMSO;2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-;3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione;3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione;CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
CBNumber:
CB98096800
Molecular Formula:
C17H12N2O5
Molecular Weight:
324.29
MDL Number:
MFCD33029299
MOL File:
2407829-65-4.mol
Last updated:2025-04-17 18:22:24

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Properties

Boiling point 680.0±50.0 °C(Predicted)
Density 1.587±0.06 g/cm3(Predicted)
solubility DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl)
form Solid
pka 8.27±0.20(Predicted)
color Light green to green

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals DC42464 CRBNmodulator-1 >98% 2407829-65-4 100mg $750 2021-12-16 Buy
DC Chemicals DC42464 CRBNmodulator-1 >98% 2407829-65-4 1g $2900 2021-12-16 Buy
Product number Packaging Price Buy
DC42464 100mg $750 Buy
DC42464 1g $2900 Buy

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Chemical Properties,Uses,Production

Uses

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

Biological Activity

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

IC 50

Cereblon

References

[1]. Nathanael Gray, et al. New crbn modulators. WO2020006262A1.

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Suppliers

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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Spectrum

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- WUN-29654 CRBN modulator-1 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor 3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione 3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione CRBN modulator-1, 10 mM in DMSO 2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione 2407829-65-4