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ChemicalBook >> CAS DataBase List >>Varenicline tartrate

Varenicline tartrate

CAS No.
375815-87-5
Chemical Name:
Varenicline tartrate
Synonyms
CS-291;Champix;Pidifix330;Pidifix-330;CP 526555-18;Unii-82269asb48;ChaMpix tartrate;Chantix tartrate;Varniclan tartrate;Varenicline tatrate
CBNumber:
CB91011765
Molecular Formula:
C17H19N3O6
Molecular Weight:
361.35
MDL Number:
MFCD08460603
MOL File:
375815-87-5.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

Varenicline tartrate Properties

Melting point 206-208°C
storage temp. room temp
solubility DMSO: >5mg/mL
form powder
color white to beige
Stability Hygroscopic
InChI InChI=1/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/s3
InChIKey TWYFGYXQSYOKLK-UHFFFAOYSA-N
SMILES [C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C12=CC3=NC=CN=C3C=C1C1CNCC2C1 |&1:0,5,r|
NCI Dictionary of Cancer Terms varenicline tartrate
FDA UNII 82269ASB48

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P264-P270-P273-P301+P312-P391-P501
Hazard Codes  Xn,N,T,F
Risk Statements  22-50-39/23/24/25-23/24/25-11
Safety Statements  22-57-45-36/37-16-7
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
NFPA 704
0
2 0

Varenicline tartrate price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0004 Varenicline tartrate ≥98% (HPLC) 375815-87-5 5mg $149 2024-03-01 Buy
Sigma-Aldrich PZ0004 Varenicline tartrate ≥98% (HPLC) 375815-87-5 25mg $591 2024-03-01 Buy
Cayman Chemical 15030 Varenicline (tartrate) ≥98% 375815-87-5 5mg $106 2024-03-01 Buy
Cayman Chemical 15030 Varenicline (tartrate) ≥98% 375815-87-5 10mg $198 2024-03-01 Buy
Cayman Chemical 15030 Varenicline (tartrate) ≥98% 375815-87-5 25mg $467 2024-03-01 Buy
Product number Packaging Price Buy
PZ0004 5mg $149 Buy
PZ0004 25mg $591 Buy
15030 5mg $106 Buy
15030 10mg $198 Buy
15030 25mg $467 Buy

Varenicline tartrate Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther

Uses

Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.

Uses

Nicotinic a4? acetylcholine receptor partial agonist. Aid in smoking cessation.

Definition

ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.

brand name

Chantix (Pfizer).

Biological Activity

Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .

Biochem/physiol Actions

Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.

storage

Room temperature

249296-44-4
87-69-4
375815-87-5
Synthesis of Varenicline tartrate from Varenicline and L(+)-Tartaric acid

Varenicline tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 320)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1001 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18151 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9087 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58

View Lastest Price from Varenicline tartrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Varenicline Tartrate pictures 2024-11-19 Varenicline Tartrate
375815-87-5
 US $30.00-73.00 / mg ≥95% 10g TargetMol Chemicals Inc.
Varenicline tartrate pictures 2024-11-01 Varenicline tartrate
375815-87-5
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
Varenicline tartrate pictures 2024-10-25 Varenicline tartrate
375815-87-5
 US $30.00-10.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.

Varenicline tartrate Spectrum

VARENICLINE TARTRATE Varenicline tartrate for research 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate Champix CP 526555-18 ,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro- 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepinetartrate 6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) Unii-82269asb48 7,8,9,10-Tetrahydro- ChaMpix tartrate Chantix tartrate Varenicline tatrate 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate Varenicline tartrate solution 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino-[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate Varenicline Tartarate CS-291 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-Dihydroxysuccinic Acid Varenicline tartrate USP/EP/BP Varenicline Tartrate DISCONTINUED Varenicline Tartrate (CP 526555-18) Pidifix330 Pidifix-330 TLF3617 Pidifix 330 Varniclan tartrate Vernicline Tartrate API 375815-87-5 75815-87-5 C13H13N3C4H6O6 Heterocycles Intermediates & Fine Chemicals Heterocyclic Compounds Inhibitors Chantix, Champix APIs Pfizer compounds Pharmaceuticals