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ChemicalBook >> CAS DataBase List >>N,N-Dimethylaniline

N,N-Dimethylaniline

CAS No.
121-69-7
Chemical Name:
N,N-Dimethylaniline
Synonyms
DMA;N,N-dimethylanilin;Dimethylanilin;DIMETHYLPHENYLAMINE;DIMETHYLAMINOBENZENE;N,N-Dimethylaniline,99%;N,N-Dimethylbenzenamine;N,N-dimethyl-Benzenamine;Benzenamine,N,N-dimethyl-;HLADM
CBNumber:
CB6852937
Molecular Formula:
C8H11N
Molecular Weight:
121.18
MDL Number:
MFCD00008304
MOL File:
121-69-7.mol
Last updated:2024-12-18 14:08:57

N,N-Dimethylaniline Properties

Melting point 1.5-2.5 °C (lit.)
Boiling point 193-194 °C (lit.)
Density 0.956 g/mL at 25 °C (lit.)
vapor density 3 (vs air)
vapor pressure 2 mm Hg ( 25 °C)
refractive index n20/D 1.557(lit.)
Flash point 158 °F
storage temp. Store below +30°C.
solubility 1.2g/l
pka 5.15(at 25℃)
form Liquid
color Clear yellow
Relative polarity 0.179
PH 7.4 (1.2g/l, H2O, 20℃)
explosive limit 1.2-7%(V)
Viscosity 6.78mm2/s
Water Solubility 1 g/L (20 ºC)
Merck 14,3234
BRN 507140
Henry's Law Constant 4.98(x 10-6 atm?m3/mol) at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits NIOSH REL: TWA 5 ppm (25 mg/m3), STEL 10 ppm (50 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm, STEL 10 ppm (adopted).
Dielectric constant 4.4000000000000004
Stability Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, chloroformates, halogens. Combustible.
InChIKey JLTDJTHDQAWBAV-UHFFFAOYSA-N
LogP 1.171 at 35℃
Indirect Additives used in Food Contact Substances N,N-DIMETHYLBENZENAMINE
CAS DataBase Reference 121-69-7(CAS DataBase Reference)
EWG's Food Scores 4
FDA UNII 7426719369
IARC 3 (Vol. 57) 1993
NIST Chemistry Reference Benzenamine, N,N-dimethyl-(121-69-7)
EPA Substance Registry System N,N-Dimethylaniline (121-69-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H351-H411
Precautionary statements  P201-P273-P280-P301+P310-P302+P352+P312-P304+P340+P311
Hazard Codes  T,N
Risk Statements  61-20/21-51/53-40-23/24/25
Safety Statements  53-45-61-36/37-28A-28
OEB A
OEL TWA: 5 ppm (25 mg/m3), STEL: 10 ppm (50 mg/m3) [skin]
RIDADR  UN 2253 6.1/PG 2
WGK Germany  3
RTECS  BX4725000
F  8
Autoignition Temperature 370 °C DIN 51794
TSCA  Yes
HS Code  2921 42 00
HazardClass  6.1
PackingGroup  II
Hazardous Substances Data 121-69-7(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1.41 ml/kg (Smyth)
IDLA 100 ppm
NFPA 704
2
3 0

N,N-Dimethylaniline price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.03060 N,N-Dimethylaniline for synthesis 121-69-7 100mL $33.5 2024-03-01 Buy
Sigma-Aldrich 8.03060 N,N-Dimethylaniline for synthesis 121-69-7 500mL $47.3 2024-03-01 Buy
Sigma-Aldrich 8.03060 N,N-Dimethylaniline for synthesis 121-69-7 1L $63.9 2024-03-01 Buy
Sigma-Aldrich 8.03060 N,N-Dimethylaniline for synthesis 121-69-7 2.5L $104 2024-03-01 Buy
Sigma-Aldrich 407275 N,N-Dimethylaniline purified by redistillation, ≥99.5% 121-69-7 100ml $83.5 2024-03-01 Buy
Product number Packaging Price Buy
8.03060 100mL $33.5 Buy
8.03060 500mL $47.3 Buy
8.03060 1L $63.9 Buy
8.03060 2.5L $104 Buy
407275 100ml $83.5 Buy

N,N-Dimethylaniline Chemical Properties,Uses,Production

Description

DMA, an aromatic amine, is a straw-coloredliquid with a characteristic amine-like odor. It turns brownon contact with air. Molecular weight= 121.20; Boilingpoint= 192℃; Freezing/Melting point = 2.2℃; Vaporpressure = 1 mmHg at 20℃; Flash point = 61℃;Autoignition temperature= 371℃. Explosive limits:LEL = 1%; UEL= 7%. Insoluble in water.

Chemical Properties

N,N-Dimethylaniline is a light yellow to light brown oily liquid. Has a pungent odor. Soluble in ethanol, chloroform, ether and aromatic organic solvents, slightly soluble in water.It is a tertiary amine used in the synthesis of several triarylmethane dyes like malachite green. It is also used in the synthesis of a magnetic gram stain for the detection of bacteria.

Physical properties

Straw to brown-colored oily liquid with a characteristic amine-like odor. Odor threshold concentration is 13 ppb (quoted, Amoore and Hautala, 1983).

Uses

N,N-dimethylaniline is an important dye intermediate. It can be used to prepare alkaline yellow, Crystal Violet 5BN, basic magenta green, basic lake blue BB, basic brilliant blue R, cationic red 2BL, brilliant red 5GN, violet 3BL, brilliant blue, etc. In the pharmaceutical industry, the product can be used to manufacture cefazolin V, sulfamonomethoxine, Sulfadoxine, fluorocytosine, etc. moreover, It can be used as an intermediate to vanillin, a stabilizer for colorimetric peroxidase determination or as a reagent in chemical synthesis.

Uses

N,N-Dimethylaniline is used in production of dyestuffs, as a solvent, a reagent in methylation reactions, and a hardener in fiberglass reinforced resins.

Production Methods

N,N-Dimethylaniline is made by heating aniline, methyl alcohol and sulfuric acid under pressure, followed by hydrolysis of the sulfate formed with sodium hydroxide to the free base (Windholz et al 1983). United States production in 1975 was estimated at 4,600 metric tons (HSDB 1989).

Definition

ChEBI: N,N-dimethylaniline is a tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups. It is a tertiary amine and a dimethylaniline.

General Description

N,N-Dimethylaniline appears as a yellow to brown colored oily liquid with a fishlike odor. Less dense than water and insoluble in water. Flash point 150°F. Toxic by ingestion, inhalation, and skin absorption. Used to make dyes and as a solvent.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Explosive decomposition occurred when finely divided benzoyl peroxide was allowed to react with N,N-Dimethylaniline by breaking an ampoule containing 0.5 grams of dimethylaniline in an autoclave, NFPA 491M, 1991. This result may be expected with other peroxides and various oxidants.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Health Hazard

Clinical signs of intoxication with N,N-dimethylaniline in man are headaches, cyanosis, dizziness, labored breathing, paralysis and convulsions (HSDB 1989). It is absorbed through the skin to produce a dangerous methemoglobinemia (Gosselin 1984). Treatment is similar to that of aniline with the object of managing methemoglobinemia.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Flammability and Explosibility

Non flammable

Industrial uses

N,N-Dimethylaniline is used as chemical intermediate in the manufacturing of vanillin, Michler's ketone, and dyes such as Acid Red 2, Basic Green 4 and Basic Violet 1 (Northcott 1978). It is also used as a solvent and an activator for polyesters and as an alkylating agent (Beard and Noe 1981). It is used as an acid scavenger or accepter in the manufacture of beta-lactam antibiotics such as penicillin and cephalosporin (Nachtmann and Gstrein 1981).

Safety Profile

Suspected carcinogen with equivocal tumorigenic data. Human poison by ingestion. Moderately toxic by inhalation and skin contact. A skin irritant. Human systemic effects by ingestion: nausea or vomiting. Physiological action is similar to, but less toxic than, adne. A central nervous system depressant. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Explodes on contact with benzoyl peroxide or disopropyl peroxydicarbonate. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits htghly toxic fumes of adne and NOx. See also ANILINE.

Potential Exposure

Tumorigen,Mutagen, Human Data; Primary Irritant. This material isused as a chemical intermediate in the manufacture of manydyes and rubber chemicals; solvent, emulsifier, and analytical reagent.

Carcinogenicity

A 2-year corn oil gavage bioassay conducted by NTP in F344/N rats (0.3 or 30 mg/kg) and B6C3F1 mice (0, 15, or 30 mg/kg) for 103 weeks concluded that there was some evidence of carcinogenic activity for male F344/N rats as indicated by the increased incidences of sarcomas or osteosarcomas in the spleen; there was no evidence of carcinogenic activity in the female rats or male mice; there was equivocal evidence of carcinogenic activity for female mice as indicated by an increased incidence of squamous cell papillomas of the forestomach. Both rats and mice could have tolerated doses higher than those used in these studies.

Environmental Fate

Photolytic. A rate constant of 1.48 x 10-10 cm3/molecule?sec was reported for the reaction of N,N-dimethylaniline and OH radicals in air at room temperature (Atkinson et al., 1987).
Chemical/Physical. Products identified from the gas-phase reaction of ozone with N,Ndimethylaniline in synthetic air at 23 °C were: N-methylformanilide, formaldehyde, formic acid, hydrogen peroxide, and a nitrated salt having the formula: [C6H6NH(CH3)2]+NO3 - (Atkinson et al., 1987). Reacts with acids forming water-soluble salts.

Metabolism

Ν,Ν-Dimethylaniline undergoes N-demethylation, N-oxidation, and ring hydroxylation in animals. Urinary metabolites produced by dogs and rabbits injected with this compound included 4-aminophenol, 4-dimethylaminophenol, 2-aminophenol and N-methylaniline (Williams 1959; Kiese and Renner 1974). N-oxidation, N-demethylation and ring hydroxylation of Ν,Ν-dimethylaniline was demonstrated in vitro using liver microsomal preparations from pigs, rats, rabbits, chickens, and guinea pigs (Fish et al 1955; Zeigler and Pettit 1964, 1966; Abou-Donia and Menzel 1968). N-oxidation was also demonstrated using whole homogenate of human liver (Zeigler and Gold 1971; Rane 1974). Evidence has been obtained with rabbit liver microsomes for two pathways for Ν,Ν-dimethylaniline N-oxidation (Hlavica and Kehl 1977). One pathway involves cytochrome P-450 while the second makes use of flavin-containing monooxygenase. N,N-Dimethylaniline was also metabolized to formaldehyde in the nasal and respiratory mucosa of Fischer 344 rats (McNulty et al 1983). Alveolar type II cells from rabbit and rat lungs catalyzed the N-oxidation of this compound (Devereux and Fouts 1974; Ohmiya and Mehendale 1981). The microsomal preparation from rat seminal vesicles when fortified with arachidonic acid catalyzed the dealkylation of N,Ndimethylaniline (Sivarajah et al 1982).

Shipping

This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS.” It falls in HazardClass 6.1 and Packing Group II.

Purification Methods

Primary and secondary amines (including aniline and monomethylaniline) can be removed by refluxing for 4-5hours with excess acetic anhydride, and then fractionally distilling. Crocker and Jones (J Chem Soc 1808 1959) used four volumes of acetic anhydride, then distilled off the greater part of it, and dissolved the residue in ice-cold dilute HCl. Non-basic materials were removed by ether extraction, then the dimethylaniline was liberated with ammonia, extracted with ether, dried, and distilled under reduced pressure. Metzler and Tobolsky (J Am Chem Soc 76 5178 1954) refluxed with only 10% (w/w) of acetic anhydride, then cooled and poured it into excess 20% HCl, which, after cooling, was extracted with diethyl ether. (The amine hydrochloride remains in the aqueous phase.) The HCl solution was cautiously made alkaline to phenolphthalein, and the amine layer was drawn off, dried over KOH and fractionally distilled under reduced pressure, under nitrogen. Suitable drying agents for dimethylaniline include NaOH, BaO, CaSO4, and CaH2. Other purification procedures include the formation of the picrate (m 163o from Me2CO or EtOH/H2O), prepared in *benzene solution and crystallised to constant melting point, then decomposed with warm 10% NaOH and extracted into ether: the extract was washed with water and distilled under reduced pressure. The oxalate salt has also been used for purification. The base has been fractionally crystallised by partial freezing and also from aqueous 80% EtOH then from absolute EtOH. It has been distilled from zinc dust, under nitrogen. [Beilstein 12 H 141, 12 I 151, 12 II 2, 12 III 245, 12 IV 243.]

Incompatibilities

Forms explosive mixture with air.Contact with strong oxidizers, strong acids, benzoyl peroxide may cause fire and explosion hazard. Contact withhypochlorite bleaches form explosive chloramines.Incompatible with anhydrides, isocyanates, aldehydes.

References

N,N-Dimethylaniline and 1-(trifluoromethyl)benzene-functionalized tetrakis(ethynyl)pyrenes: synthesis, photophysical, electrochemical and computational studies DOI:10.1016/J.TET.2011.12.066
Friedel-Crafts Reaction of N,N-Dimethylaniline with Alkenes Catalyzed by Cyclic Diaminocarbene-Gold(I) Complex doi: 10.1038/s41598-018-29854-0
Groundwater Chemicals Desk Reference DOI:10.5860/choice.27-6127
Patty's Toxicology 6-Volume Set-Wiley (2012)
Proctor Proctor and Hughes' chemical hazards of the workplace (5th edn) Wiley Interscience DOI:10.1002/JAT.1034
Nitrogen and phosphorus solvents DOI:10.1016/c2009-0-01359-2
Purification of Laboratory Chemicals DOI:10.5860/choice.50-6768

124-38-9
100-61-8
121-69-7
Synthesis of N,N-Dimethylaniline from Carbon dioxide and N-Methylaniline
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View Lastest Price from N,N-Dimethylaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N-Dimethylaniline pictures 2024-12-20 N,N-Dimethylaniline
121-69-7
 US $1.00 / KG 1KG ≥99% 2000mt/year Jinan Finer Chemical Co., Ltd
N,N-Dimethylaniline pictures 2024-11-20 N,N-Dimethylaniline
121-69-7
 US $0.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
N,N-Dimethylaniline pictures 2024-11-07 N,N-Dimethylaniline
121-69-7
 US $0.00 / kg 1kg 98% 1000000 Hebei Jingbo New Material Technology Co., Ltd
Aniline, N,N-dimethyl- N,N-Dimethylbenzeneamine N,N-Dimethyl-N-phenylamine N,N-Dimethylphenylamine N,N-DIMETHYLACETATE N-ACETYLDIMETHYLAMINE N,N-Dimethylaniline [for Biochemical Research] NCI-C56428 nl63-10p Versneller NL 63/10 versnellernl63/10 Xylidene N,N-Dimethylaniline N,N-Dimethylaniline, synthesis grade N,N-Dimethylaniline, reagent grade N,N-DIMETHYLANILINE FOR SYNTHESIS NSC 7195 DMA, N-Phenyldimethylamine N,N-DiMethylaniline purified by redistillation, >=99.5% N,N-DiMethylaniline ReagentPlus(R), 99% N,N-DiMethylaniline, 98+% N,N-DiMethylaniline, 99% 1LT N,N-DiMethylaniline, 99% 5ML N.N-Dimethylan D6S222E HLADM RING6 N,N-dimethylaniline-15N N,N-dimethylaniline-methyl-13C2 Dimethylaniline,N-N-dimethylphenylamine Dimethylphylamine Dwumetyloanilina dwumetyloanilina(polish) N,N-(Dimethylamino)benzene n,n-dimethyl-anilin n,n-dimethyl-benzenamin LABOTEST-BB LT00782487 AKOS BBS-00004263 AKOS BBS-00004374 AMINODIMETHYLBENZENE ACETYL DIMETHYLAMINE NN-Dimethylaniline 99.0 % (GLC) for analysis N. N. DIMETHYL ACETAMIDE (TECH. GRADE) Dimethylaniline (DMA) N N-DIMETHYLANILINE REAGENTPLUS(TM) & N,N-DIMETHYLANILINE, REAGENTPLUS, 99% N,N-DIMETHYLANILINE, REDISTILLED, 99.5+% N,N-DIMETHYLANILINE, 1ML, NEAT N,N-DimethylanilineCertified N,N-DIMETHYLANILINE,REAGENT 4-DIMETHYLAMINOBENZENE DIMETHYL-4-AMINOAZOBENZENE Aniline dimethyl N,N-dimethylaminobenzenamine N,N,DIMETHYLANILINE pure N,N-DIMETHYLANILINE extrapure AR N,N-Dimethylbenzeneamine Xylidene N,N-Dimethyl Aniline (DMA)