2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
- CAS No.
- 937820-89-8
- Chemical Name:
- 2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
- Synonyms
- JC2-11;JC2-11, 10 mM in DMSO;(E)-1-(3-Fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one;(2E)-1-(3-Fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
- CBNumber:
- CB612970393
- Molecular Formula:
- C17H15FO4
- Molecular Weight:
- 302.3
- MDL Number:
- MOL File:
- 937820-89-8.mol
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Chemical Properties,Uses,Production
Uses
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
in vivo
JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibits the release of caspase-1 (p20) and IL-1β in non-canonical (NC) inflammatory bodies, and weakens the activation of NC inflammatory bodies of C57BL/6 mice model[1].
| Animal Model: | C57BL/6 mice (8 weeks, female)[1]. |
| Dosage: | 250 μg/mouse. |
| Administration: | Intraperitoneal injection; single dose. |
| Result: | Exhibited inhibitory effect on NC inflammatory body. |
IC 50
NLRP3 inflammasome
References
[1] Lee G, et al, JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484. DOI:10.1038/s41598-022-27129-3
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6345 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5003 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24739 | 58 |
