Terevalefim
- CAS No.
- 1070881-42-3
- Chemical Name:
- Terevalefim
- Synonyms
- Terevalefim;Terevalefim（ANG-3777）;Terevalefim, 10 mM in DMSO;(E)-3-(2-(thiophen-2-yl)vinyl)-1H-pyrazole;1H-Pyrazole, 3-[(1E)-2-(2-thienyl)ethenyl]-;3-[(E)-2-(thiophen-2-yl)ethenyl]-2H-pyrazole;ANG-3777,Terevalefim,injury,acute,inhibit,ANG 3777,AKI,kidney,ANG3777,transplantation,c-Met/HGFR,HGF,Inhibitor
- CBNumber:
- CB54868672
- Molecular Formula:
- C9H8N2S
- Molecular Weight:
- 176.24
- MDL Number:
- MOL File:
- 1070881-42-3.mol
| Boiling point | 369.3±11.0 °C(Predicted) |
|---|---|
| Density | 1.318±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (567.41 mM; Need ultrasonic) |
| pka | 14.05±0.10(Predicted) |
| form | Solid |
| color | White to light brown |
| FDA UNII | GG91UXK2M5 |
Terevalefim Chemical Properties,Uses,Production
Description
Terevalefim (ANG-3777) is a hepatocyte growth factor (HGF) mimetic that in preclinical and phase 2 studies has demonstrated the ability to activate the c-Met receptor and the pathways associated with that activation, improving renal function in induced-AKI in animals and long-term graft function occurring in renal transplantation recipients with signs of DGF[1-2].
Uses
Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].
Biological Functions
ANG-3777 (Terevalefim) is an HGF mimetic that in vitro induces the same c-Met cascades and cellular effects as endogenous HGF. In animals, ANG-3777 stimulates tubular repair and regeneration, resulting in improved renal function following ischemia reperfusion injury. In humans, ANG-3777 has been shown to improve renal function up to 1 year after kidney transplantation in patients with signs of delayed graft function[1].
in vitro
In vitro, ANG-3777 reduces apoptosis and increases cell proliferation, migration, morphogenesis, and angiogenesis in injured kidneys. In animal models, ANG-3777 mitigates the effects of renal damage secondary to ischemia reperfusion injury and nephrotoxic chemicals[1].
in vivo
In vivo, Terevalefim results in dimerization and phosphorylation, and thus activation of the c-Met receptor, followed by activation of c-Met signaling cascades. The presence of c-Met is needed for ANG-3777 activity, and ANG-3777 selectively phosphorylates c-Met. Furthermore, c-Met phosphorylation induced by ANG-3777 occurs in a dose- and time-dependent manner with selective phosphorylation of c-Met and its downstream effector of ERK. No phosphorylation of IFGR, Tie2, EGFR, or FGFR occurs[2].
References
[1] Ayad S, et al. Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery–Associated Acute Kidney Injury. Kidney International Reports, 2020; 5: 2325–2332.
[2] Vincenti F, et al. Phase 3 trial design of the hepatocyte growth factor mimetic ANG-3777 in renal transplant recipients with delayed graft function. Kidney International Reports, 2021; 6: 296-303.
Terevalefim Preparation Products And Raw materials
Raw materials
Preparation Products
Terevalefim Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Shanghai Gugang New Materials Technology Co. Ltd. | 021-51317962 | 296935822@qq.com | China | 983 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24868 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4997 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 55710 | 58 |
| Selleck Chemicals | 400-668-6834 | info@selleck.cn | China | 12071 | 58 |
View Lastest Price from Terevalefim manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Terevalefim
1070881-42-3
|
US $51.00-222.00 / mg | 99.53% | 10g | TargetMol Chemicals Inc. |
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- Terevalefim
1070881-42-3
- US $51.00-222.00 / mg
- 99.53%
- TargetMol Chemicals Inc.