Cyclophosphamide monohydrate
- CAS No.
- 6055-19-2
- Chemical Name:
- Cyclophosphamide monohydrate
- Synonyms
- CPA;Cyclophosphamide sterile;CYTOXAN;ENDOXON;Procy-tox;Cycloblastin;-2monohydrate;endoxanmonohydrate;TIMTEC-BB SBB003026;cyclophosphamide,CTX
- CBNumber:
- CB5345867
- Molecular Formula:
- C7H17Cl2N2O3P
- Molecular Weight:
- 279.1
- MDL Number:
- MFCD00149395
- MOL File:
- 6055-19-2.mol
Melting point | 49-51 °C (lit.) |
---|---|
Flash point | >230 °F |
storage temp. | 2-8°C |
solubility | H2O: 0.1 g/mL, clear, colorless |
form | Crystals or Crystalline Powder |
color | White to almost white |
Water Solubility | 40 g/L |
Merck | 14,2747 |
BRN | 8167897 |
Stability | Hygroscopic |
InChIKey | PWOQRKCAHTVFLB-UHFFFAOYSA-N |
CAS DataBase Reference | 6055-19-2(CAS DataBase Reference) |
EWG's Food Scores | 6 |
FDA UNII | 8N3DW7272P |
IARC | 1 (Vol. 26, Sup 7, 100A) 2012 |
EPA Substance Registry System | Cyclophosphamide monohydrate (6055-19-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H340-H350-H360FD | |||||||||
Precautionary statements | P202-P264-P270-P280-P301+P310-P405 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 45-25-61-46-36/37/38-23/24/25 | |||||||||
Safety Statements | 53-45-37/39-26 | |||||||||
RIDADR | UN 3464 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | RP6157750 | |||||||||
F | 10 | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29349990 | |||||||||
NFPA 704 |
|
Cyclophosphamide monohydrate price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 93813 | Cyclophosphamide monohydrate analytical standard | 6055-19-2 | 100mg | $69.5 | 2024-03-01 | Buy |
Sigma-Aldrich | 239785 | CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert | 6055-19-2 | 1g | $111 | 2024-03-01 | Buy |
TCI Chemical | C2236 | Cyclophosphamide Monohydrate >98.0%(N) | 6055-19-2 | 5g | $114 | 2024-03-01 | Buy |
TCI Chemical | C2236 | Cyclophosphamide Monohydrate >98.0%(N) | 6055-19-2 | 25g | $385 | 2024-03-01 | Buy |
Cayman Chemical | 13849 | Cyclophosphamide (hydrate) ≥98% | 6055-19-2 | 1g | $32 | 2024-03-01 | Buy |
Cyclophosphamide monohydrate Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
alkylating agent in cancer therapy
Uses
An immunosuppressive, cytotoxic apoptosis inducer.
Uses
It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.
Uses
antineoplastic, alkylating agent
Uses
Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.
Definition
ChEBI: The monohydrate of cyclophosphamide.
brand name
Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).
General Description
Fine white crystalline powder with a slightly bitter taste. Little or no odor.
Air & Water Reactions
Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.
Reactivity Profile
Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.
Fire Hazard
Cyclophosphamide monohydrate is probably combustible.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Safety Profile
Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.
Cyclophosphamide monohydrate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18151 | 58 |
Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20284 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 456 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
View Lastest Price from Cyclophosphamide monohydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-12-20 | Cyclophosphamide monohydrate
6055-19-2
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | ||
2024-12-13 | Cyclophosphamide monohydrate
6055-19-2
|
US $0.00-0.00 / Kg/Drum | 1KG | 97%-103%; USP | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-11-19 | Cyclophosphamide hydrate
6055-19-2
|
US $33.00-58.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. |
- Cyclophosphamide monohydrate
6055-19-2
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
- Cyclophosphamide monohydrate
6055-19-2
- US $0.00-0.00 / Kg/Drum
- 97%-103%; USP
- WUHAN FORTUNA CHEMICAL CO., LTD
- Cyclophosphamide hydrate
6055-19-2
- US $33.00-58.00 / mg
- ≥95%
- TargetMol Chemicals Inc.
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