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ChemicalBook >> CAS DataBase List >>Cyclophosphamide monohydrate

Cyclophosphamide monohydrate

CAS No.
6055-19-2
Chemical Name:
Cyclophosphamide monohydrate
Synonyms
CPA;Cyclophosphamide sterile;CYTOXAN;ENDOXON;Procy-tox;Cycloblastin;-2monohydrate;endoxanmonohydrate;TIMTEC-BB SBB003026;cyclophosphamide,CTX
CBNumber:
CB5345867
Molecular Formula:
C7H17Cl2N2O3P
Molecular Weight:
279.1
MDL Number:
MFCD00149395
MOL File:
6055-19-2.mol
Last updated:2024-12-18 14:08:52

Cyclophosphamide monohydrate Properties

Melting point 49-51 °C (lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility H2O: 0.1 g/mL, clear, colorless
form Crystals or Crystalline Powder
color White to almost white
Water Solubility 40 g/L
Merck 14,2747
BRN 8167897
Stability Hygroscopic
InChIKey PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference 6055-19-2(CAS DataBase Reference)
EWG's Food Scores 6
FDA UNII 8N3DW7272P
IARC 1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System Cyclophosphamide monohydrate (6055-19-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H340-H350-H360FD
Precautionary statements  P202-P264-P270-P280-P301+P310-P405
Hazard Codes  T
Risk Statements  45-25-61-46-36/37/38-23/24/25
Safety Statements  53-45-37/39-26
RIDADR  UN 3464 6.1/PG 3
WGK Germany  3
RTECS  RP6157750
10
HazardClass  6.1
PackingGroup  II
HS Code  29349990
NFPA 704
1
2 0

Cyclophosphamide monohydrate price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 93813 Cyclophosphamide monohydrate analytical standard 6055-19-2 100mg $69.5 2024-03-01 Buy
Sigma-Aldrich 239785 CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert 6055-19-2 1g $111 2024-03-01 Buy
TCI Chemical C2236 Cyclophosphamide Monohydrate >98.0%(N) 6055-19-2 5g $114 2024-03-01 Buy
TCI Chemical C2236 Cyclophosphamide Monohydrate >98.0%(N) 6055-19-2 25g $385 2024-03-01 Buy
Cayman Chemical 13849 Cyclophosphamide (hydrate) ≥98% 6055-19-2 1g $32 2024-03-01 Buy
Product number Packaging Price Buy
93813 100mg $69.5 Buy
239785 1g $111 Buy
C2236 5g $114 Buy
C2236 25g $385 Buy
13849 1g $32 Buy

Cyclophosphamide monohydrate Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

alkylating agent in cancer therapy

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 449)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd
+8617732866630 bess@weibangbio.com China 18151 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 hbjbtech@163.com China 1000 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20284 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 1015 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368 sales@sjar-tech.com China 456 58
HebeiShuoshengImportandExportco.,Ltd
+86-18532138899 +86-18532138899 L18532138899@163.com China 939 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18751 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60

View Lastest Price from Cyclophosphamide monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclophosphamide monohydrate  pictures 2024-12-20 Cyclophosphamide monohydrate
6055-19-2
US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd
Cyclophosphamide monohydrate pictures 2024-12-13 Cyclophosphamide monohydrate
6055-19-2
US $0.00-0.00 / Kg/Drum 1KG 97%-103%; USP 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Cyclophosphamide hydrate pictures 2024-11-19 Cyclophosphamide hydrate
6055-19-2
US $33.00-58.00 / mg ≥95% 10g TargetMol Chemicals Inc.
2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE ENDOXON CYCLOPHOSPHAMIDE HYDRATE CYCLOPHOSPHAMIDE MONOHYDRATE CYCLOPHOSPHAMID MONOHYDRATE bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate TIMTEC-BB SBB003026 > 100 Kgyclophosphamide monohydrate Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester~Cyclophosphane cyclophosphamide isopac Cyclophos phamide USP CYCLOPHOSPHAMIDE MONOHYDRATE, 98+% CyclophosphamideSterile,Usp28 Cyclophosphamidemonohaydrate CYCLOPHOSPHAMIDE 1-HYDRATE 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate CyclophosphaMide,awater 2-(Bis(2-chloroethyl)aMino)-1,3,2-oxazaphosphinane 2-oxide hydrate 2-oxide-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, hydrate (1:1) Bis(2-chloroethyl)phosphoramide cyclic propanolamide este Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo -2monohydrate cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm endoxanmonohydrate n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxaphosphorin-2-amine,2-oxidemono N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphos-phorin-2-amine2-oxide n,n-bis(beta-chloroethyl)-n’,o-propylenephosphoricacidesteramidemonohydra n,n-bis(beta-chloroethyl)-n’,o-trimethylenephosphoricacidesterdiamidemono Procy-tox n,n-bis(beta-cloraethyl)n’-o-propylenphosphorildiamidmonohydratum N,N-Bis-2-chloroethyl-N’,O-propylenephosphoricesterdiamidemonohydrate n,n-di(2-chloroethyl)amino-n,o-propylenephosphoricacidesterdiamidemonohy CYCLOPHOPHAMIDEMONOHYDRATE CYCLOPHOSPHAMIDE,MONOHYDRATE,USP CYCLOPHOSPHAMIDE(HYDRATED) cyclophosphamide,CTX 2h-1,3,2-oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, mo (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-o xide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridine monohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydra cyclophosphamide hydrate cyclophosphamide monohydrate endoxan monohydrate Cycloblastin Cyclophosphamide monohydrate, 97+% Cytoxan, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate N,N-Bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine hydrate CyclophosphamideUsp27 Cyclophosphamide monohydrate,2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan Cyclophosphamide (500 mg) (FOR U.S. SALE ONLY) Cyclophosphamide mon Cyclophosphamide (500 mg) (International Restricted Sales Item) (2S)-2-[bis(2-chloroethyl)aMino]-1,3,2$l^{5}-oxazaphosphinan-2-one CyclophosphaMide Monohydrate, 97% 1GR