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ChemicalBook >> CAS DataBase List >>E3 ligase Ligand-Linker Conjugates 6 Free Base

E3 ligase Ligand-Linker Conjugates 6 Free Base

CAS No.
2010159-60-9
Chemical Name:
E3 ligase Ligand-Linker Conjugates 6 Free Base
Synonyms
AHPC-PEG2-NH2;VH032-PEG2-NH2;S)-AHPC-PEG2-NH2;(S,R,S)-AHPC-PEG2-NH2;PROTACs Related Compound 6;VHL Ligand-Linker Conjugates 3;（S,R,S)-AHPC-acetamido-O-C2-amine HCI;(S,R. S)-AHPC-PEG2-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 6 Free Base;(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)
CBNumber:
CB44797052
Molecular Formula:
C28H41N5O6S
Molecular Weight:
575.73
MDL Number:
MFCD31728145
MOL File:
2010159-60-9.mol
Last updated:2025-04-18 09:52:21

E3 ligase Ligand-Linker Conjugates 6 Free Base Properties

Boiling point 856.9±65.0 °C(Predicted)
Density 1.249±0.06 g/cm3(Predicted)
solubility Soluble in Water, DMSO, Methanol
pka 13.54±0.46(Predicted)
form Solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934100090

E3 ligase Ligand-Linker Conjugates 6 Free Base price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
BroadPharm BP-24451 (S,R.S)-AHPC-PEG2-aminehydrochloridesalt 98% 2010159-60-9 100mg $540 2021-12-16 Buy
DC Chemicals 027596 (S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase) 2010159-60-9 001 $550 2021-12-16 Buy
DC Chemicals 027596 (S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase) 2010159-60-9 002 $950 2021-12-16 Buy
Product number Packaging Price Buy
BP-24451 100mg $540 Buy
027596 001 $550 Buy
027596 002 $950 Buy

E3 ligase Ligand-Linker Conjugates 6 Free Base Chemical Properties,Uses,Production

Description

(S, R, S)-AHPC-PEG2-amine is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG2 unit to empower drug research & discovery. It is reactive with NHS ester or carboxylic acid.

Uses

(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC 50

VHL

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912

E3 ligase Ligand-Linker Conjugates 6 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

E3 ligase Ligand-Linker Conjugates 6 Free Base Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32283 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18129 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6585 65
Aikon International Limited 025-58859352 18068836627 sales01@aikonchem.com China 15083 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4838 58
Shanghai SPAR pharmaceutical technology co., LTD 021-000000 admin@jingshipharmatech.com China 9958 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1592 58

View Lastest Price from E3 ligase Ligand-Linker Conjugates 6 Free Base manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-PEG2-NH2 pictures 2024-04-02 (S,R,S)-AHPC-PEG2-NH2
2010159-60-9
 US $0.00 / mg 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.
E3 ligase Ligand-Linker Conjugates 6 Free Base (2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide (S,R,S)-AHPC-PEG2-NH2 VH032-PEG2-NH2 VHL Ligand-Linker Conjugates 3 PROTACs Related Compound 6 (S,R. S)-AHPC-PEG2-amine hydrochloride salt （S,R,S)-AHPC-acetamido-O-C2-amine HCI (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) (2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide S)-AHPC-PEG2-NH2 (S,R,S) AHPC PEG2 NH2,Inhibitor,E3 ligase Ligand-Linker Conjugates 6,inhibit,(S,R,S)AHPCPEG2NH2,(S,R,S)-AHPC-PEG-2-NH2,E3 Ligase Ligand-Linker Conjugates (2S,4R)-1-[(2S)-2-{2-[2-(2-aminoethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide AHPC-PEG2-NH2 2010159-60-9 C28H41N5O6S