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ChemicalBook >> CAS DataBase List >>2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

CAS No.
99754-06-0
Chemical Name:
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
Synonyms
ONO-RS-082;2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID;2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid;4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid;2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt;4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363);4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
CBNumber:
CB3723445
Molecular Formula:
C21H22ClNO3
Molecular Weight:
371.86
MDL Number:
MFCD00210755
MOL File:
99754-06-0.mol
Last updated:2024-11-19 20:33:22

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Properties

Melting point 175-177℃
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
color white
Sensitive Light Sensitive
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P501
Hazard Codes  N
Risk Statements  50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
HazardClass  9

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O0766 ONO-RS-082 ≥97% (HPLC) 99754-06-0 5mg $122 2024-03-01 Buy
Sigma-Aldrich O0766 ONO-RS-082 ≥97% (HPLC) 99754-06-0 25mg $475 2024-03-01 Buy
Alfa Aesar J67444 ONO-RS-082, 98% 99754-06-0 20mg $141 2023-06-20 Buy
Cayman Chemical 20243 ONO-RS-082 ≥98% 99754-06-0 100mg $243 2024-03-01 Buy
Cayman Chemical 20243 ONO-RS-082 99754-06-0 25mg $130 2024-03-01 Buy
Product number Packaging Price Buy
O0766 5mg $122 Buy
O0766 25mg $475 Buy
J67444 20mg $141 Buy
20243 100mg $243 Buy
20243 25mg $130 Buy

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Chemical Properties,Uses,Production

Description

ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5

Uses

ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor.

in vitro

previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].

References

1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197 2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361 3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530 4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004 5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22345 58
Aikon International Limited 025-66113011 18112977050 cb6@aikonchem.com China 15494 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49312 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44806 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58

View Lastest Price from 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ONO-RS-082 pictures 2024-11-19 ONO-RS-082
99754-06-0
 US $31.00-72.00 / mg 99.35% 10g TargetMol Chemicals Inc.
  • ONO-RS-082 pictures
  • ONO-RS-082
    99754-06-0
  • US $31.00-72.00 / mg
  • 99.35%
  • TargetMol Chemicals Inc.

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Spectrum

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID ONO-RS-082 2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid 2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid (E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid (E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363) 4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid Benzoic acid, 4-chloro-2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]- 4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid lung,neutrophils,hepoxilin,ONO RS 082,prostaglandin,arachidonic,inhibit,inflammation,Phospholipase,Inhibitor,ONORS082,acid 4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid 99754-06-0