ALPHA-AMANITIN
- CAS No.
- 23109-05-9
- Chemical Name:
- ALPHA-AMANITIN
- Synonyms
- α-Amanitin;A-AMANITIN;Aids004473;α-Amatoxin;Aids-004473;AMANITIN, A-;ALPHA-AMANTIN;ALPHA-AMANITIN;alpha-amatoxin;ALPHA-AMANTINE
- CBNumber:
- CB3142945
- Molecular Formula:
- C39H54N10O14S
- Molecular Weight:
- 918.98
- MDL Number:
- MFCD30207890
- MOL File:
- 23109-05-9.mol
- MSDS File:
- SDS
| Melting point | 254-255 °C(lit.) |
|---|---|
| alpha | D20 +191° |
| Boiling point | 1622.2±65.0 °C(Predicted) |
| Density | 1.1626 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| storage temp. | −20°C |
| solubility | H2O: 1.0 mg/mL |
| pka | 9.63±0.70(Predicted) |
| form | powder |
| color | white to light yellow |
| optical activity | +19120 (H2O) |
| biological source | Amanita phalloides |
| Water Solubility | Soluble to 5 mM in ethanol and to 5 mM in water |
| ε(extinction coefficient) | 13,500 at 310nm in H2O at 1M |
| Merck | 13,370 |
| BRN | 1071138 |
| InChIKey | CIORWBWIBBPXCG-PWKRRBCNNA-N |
| EWG's Food Scores | 1 |
| FDA UNII | E04K0QZ999 |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H373 | |||||||||
| Precautionary statements | P260-P264-P270-P301+P310-P314-P405 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-33-26/28 | |||||||||
| Safety Statements | 36/37/39-45-36/37-28 | |||||||||
| RIDADR | UN 3462 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BD6195000 | |||||||||
| F | 8-10-18-21 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 2934999090 | |||||||||
| Hazardous Substances Data | 23109-05-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland) | |||||||||
| NFPA 704 |
|
ALPHA-AMANITIN price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2263 | α-Amanitin from Amanita phalloides, ≥90% (HPLC), powder | 23109-05-9 | 1mg | $340 | 2024-03-01 | Buy |
| Cayman Chemical | 17898 | α-Amanitin ≥90% | 23109-05-9 | 1mg | $227 | 2024-03-01 | Buy |
| Tocris | 4025 | alpha-Amanitin ≥95%(HPLC) | 23109-05-9 | 1 | $291 | 2021-12-16 | Buy |
| Usbiological | 257178 | α-Amanitin | 23109-05-9 | 1mg | $588 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA57619 | a-Amanitin | 23109-05-9 | 5mg | $800 | 2021-12-16 | Buy |
ALPHA-AMANITIN Chemical Properties,Uses,Production
Uses
α-Amanitin has been used:
- for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
- to induce nephrotoxicity in mice renal tissues
- to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay
Biological Activity
α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.
Biochem/physiol Actions
The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
in vivo
The intravenous LD50 dose of alpha-Amanitin is 0.327 mg/kg body weight after intravenous injection into BALB/c mice. After 12 h of alpha-Amanitin injection in caudal vein, the levels of WBC, RBC and HGB decrease significantly, while those of BUN and Crea increase significantly in serum. alpha-Amanitin inhibits some genes (Hsp90b1, Irx4, etc.), whose encoded proteins regulate the RNA polymerase II activity. alpha-Amanitin down-regulates some proteins (Nmi, Trpc5, etc.) taking part in the transcription progress[1]. alpha-Amanitin has potent activity in DTC suppression. Mice injected with alpha-Amanitin (0.4 mg/kg, i.p.)-treated cells maintain their body weight, while those receiving a peritoneal injection of MKN45 cells show a constant decrease in body weight[2].
IC 50
Traditional Cytotoxic Agents
storage
Store at -20°C
ALPHA-AMANITIN Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-AMANITIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29856 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3055 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 785 | 58 |
| Hebei baicao biology science and technology co., ltd | +86-19131911055 +8617824879454 | zhang@hbbocao.com | China | 1029 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
View Lastest Price from ALPHA-AMANITIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-27 | ALPHA-AMANITIN
23109-05-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2024-05-11 | alpha-Amanitin
23109-05-9
|
US $9.00-70.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-01-08 | α-Amanitin
23109-05-9
|
US $60.00-45.00 / mg | 1mg | 99.96% | 1kg | Wuhan Boyuan Import & Export Co., LTD |
-
- ALPHA-AMANITIN
23109-05-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- alpha-Amanitin
23109-05-9
- US $9.00-70.00 / g
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- α-Amanitin
23109-05-9
- US $60.00-45.00 / mg
- 99.96%
- Wuhan Boyuan Import & Export Co., LTD